Literature summary extracted from

Fan, L.Q.; You, L.; Brown-Borg, H.; Brown, S.; Edwards, R.J.; Corton, J.C.
Regulation of phase I and phase II steroid metabolism enzymes by PPARa activators (2004), Toxicology, 204, 109-121.

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
1.14.99.12	androst-4-ene-3,17-dione + AH2 + O2	Rattus norvegicus	enzyme levels increase after exposure of rats to di-n-butyl phthalate	3-oxo-13,17-secoandrost-4-ene-17,13alpha-lactone + A + H2O	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.14.99.12	Rattus norvegicus	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
1.14.99.12	liver	-	Rattus norvegicus	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1.14.99.12	androst-4-ene-3,17-dione + AH2 + O2	-	Rattus norvegicus	3-oxo-13,17-secoandrost-4-ene-17,13alpha-lactone + A + H2O	-	?
1.14.99.12	androst-4-ene-3,17-dione + AH2 + O2	enzyme levels increase after exposure of rats to di-n-butyl phthalate	Rattus norvegicus	3-oxo-13,17-secoandrost-4-ene-17,13alpha-lactone + A + H2O	-	?

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Release 2023.1 (January 2023)