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Literature summary extracted from
- Glutathione reductase is expressed at high levels in pancreatic islet cells (2004), Redox Rep., 9, 321-324.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.8.1.7 | 1,3-bis-(2-chloroethyl) 1-nitrosourea | irreversible inhibition | Rattus norvegicus |  |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.8.1.7 | glutathione disulfide + NADPH | Rattus norvegicus | antioxidant enzyme, protects the pancreatic cell against reactive oxygen species involved in the diabetogenic agent-induced dysfunction of pancreatic-beta-cells | glutathione + NADP+ | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.8.1.7 | Rattus norvegicus | - |
7-week-old Wistar rats | - |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.8.1.7 | pancreas | localization of the enzyme in pancreatic tissue, overview | Rattus norvegicus | - |
| 1.8.1.7 | pancreatic acinar cell | pancreas, lower expression level than in islet cells | Rattus norvegicus | - |
| 1.8.1.7 | pancreatic islet | high expression level | Rattus norvegicus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.8.1.7 | glutathione disulfide + NADPH | - |
Rattus norvegicus | glutathione + NADP+ | - |
? | |
| 1.8.1.7 | glutathione disulfide + NADPH | antioxidant enzyme, protects the pancreatic cell against reactive oxygen species involved in the diabetogenic agent-induced dysfunction of pancreatic-beta-cells | Rattus norvegicus | glutathione + NADP+ | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.8.1.7 | glutathione reductase | - |
Rattus norvegicus |
| 1.8.1.7 | GR | - |
Rattus norvegicus |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 1.8.1.7 | 7 | - |
assay at | Rattus norvegicus |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.8.1.7 | NADPH | - |
Rattus norvegicus | |
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Release 2023.1 (January 2023)
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