BRENDA - Enzyme Database show

Prostaglandin and leukotriene omega-hydroxylases

Kikuta, Y.; Kusunose, E.; Kusunose, M.; Prostaglandins 68-69, 345-362 (2002)

Data extracted from this reference:

Cloned(Commentary)
EC Number
Commentary
Organism
1.14.14.94
expression in yeast; expression in yeast cells, CYP4F3
Homo sapiens
KM Value [mM]
EC Number
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
1.14.14.94
0.00064
-
leukotriene B4
CYP4F3
Homo sapiens
Localization
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
1.14.14.94
microsome
-
Homo sapiens
-
-
Molecular Weight [Da]
EC Number
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
1.14.14.94
additional information
-
the isolated cDNA encodes a protein of 520 amino acids with 59805 Da, CYP4F3
Homo sapiens
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
1.14.14.1
prostaglandin + [reduced NADPH-hemoprotein reductase] + O2
Oryctolagus cuniculus
physiological functions are the metabolic inactivation of prostaglandins and the production of 20-hydroxyeicosatetraenoic acid, CYP4A4
20-hydroxy-prostaglandin + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
?
1.14.14.94
arachidonate + [reduced NADPH-hemoprotein reductase] + O2
Homo sapiens
the enzyme is the principal arachidonate omega-hydroxylase in liver, CYP4F2
20-hydroxy-5,8,11,14-eicosatetraenoic acid + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
?
1.14.14.94
leukotriene B4 + [reduced NADPH-hemoprotein reductase] + O2
Homo sapiens
the enzyme plays a critical role in regulating the biological effect of leukotriene B4, CYP4F3
20-hydroxy-leukotriene B4 + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
?
1.14.14.94
additional information
Homo sapiens
CYP4F3B and CYP4F2 may function collaboratively as 20-HETE synthetase as well as omega-hydroxylases for leukotiene b4 and other lipoxygenase-dependent eicosanoids in human liver and other tissues
?
-
-
-
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
1.14.14.1
Oryctolagus cuniculus
-
-
-
1.14.14.94
Homo sapiens
-
-
-
Purification (Commentary)
EC Number
Commentary
Organism
1.14.14.94
CYP4F3
Homo sapiens
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
1.14.14.1
liver
CYP4A6
Oryctolagus cuniculus
-
1.14.14.1
lung
-
Oryctolagus cuniculus
-
1.14.14.1
small intestine
CYP4A7
Oryctolagus cuniculus
-
1.14.14.94
heart
CYP4F11
Homo sapiens
-
1.14.14.94
ileum
CYP4F3B is the predominant CYP4F isoform
Homo sapiens
-
1.14.14.94
kidney
CYP4F11; CYP4F2; CYP4F3B
Homo sapiens
-
1.14.14.94
liver
CYP4F11; CYP4F2; CYP4F3B is the predominant CYP4F isoform; mRNA for CYP4F8 detected
Homo sapiens
-
1.14.14.94
additional information
CYP4F2 is not expressed in myeloid cells, polymorphonuclear leukocyte; no expression of CYP4F8 in leukocytes
Homo sapiens
-
1.14.14.94
polymorphonuclear leukocyte
CYP4F3 is specifically expressed in. CYP4F3 is restricted to myeloid cells
Homo sapiens
-
1.14.14.94
prostate gland
mRNA for CYP4F8 detected
Homo sapiens
-
1.14.14.94
seminal vesicle
CYP4F8
Homo sapiens
-
1.14.14.94
skeletal muscle
CYP4F11
Homo sapiens
-
1.14.14.94
skin
CYP4F2
Homo sapiens
-
Storage Stability
EC Number
Storage Stability
Organism
1.14.14.94
-70°C, 50% losss of activity after 3 days
Homo sapiens
1.14.14.94
-70°C, no loss of activity with highly purified preparations even after 4 years
Homo sapiens
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1.14.14.1
additional information
no activity with prostaglandins of E type, CYP4A6
660409
Oryctolagus cuniculus
?
-
-
-
-
1.14.14.1
additional information
no activity with prostaglandins of E type, CYP4A7
660409
Oryctolagus cuniculus
?
-
-
-
-
1.14.14.1
prostaglandin + [reduced NADPH-hemoprotein reductase] + O2
physiological functions are the metabolic inactivation of prostaglandins and the production of 20-hydroxyeicosatetraenoic acid, CYP4A4
660409
Oryctolagus cuniculus
20-hydroxy-prostaglandin + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
1.14.14.1
prostaglandin A1 + [reduced NADPH-hemoprotein reductase] + O2
CYP4A4
660409
Oryctolagus cuniculus
20-hydroxy-prostaglandin A1 + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
1.14.14.1
prostaglandin A1 + [reduced NADPH-hemoprotein reductase] + O2
CYP4A6
660409
Oryctolagus cuniculus
20-hydroxy-prostaglandin A1 + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
1.14.14.1
prostaglandin A1 + [reduced NADPH-hemoprotein reductase] + O2
CYP4A7
660409
Oryctolagus cuniculus
20-hydroxy-prostaglandin A1 + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
1.14.14.1
prostaglandin A2 + [reduced NADPH-hemoprotein reductase] + O2
CYP4A4
660409
Oryctolagus cuniculus
20-hydroxy-prostaglandin A2 + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
1.14.14.1
prostaglandin A2 + [reduced NADPH-hemoprotein reductase] + O2
CYP4A6
660409
Oryctolagus cuniculus
20-hydroxy-prostaglandin A2 + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
1.14.14.1
prostaglandin A2 + [reduced NADPH-hemoprotein reductase] + O2
CYP4A7
660409
Oryctolagus cuniculus
20-hydroxy-prostaglandin A2 + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
1.14.14.1
prostaglandin D2 + [reduced NADPH-hemoprotein reductase] + O2
CYP4A4
660409
Oryctolagus cuniculus
20-hydroxy-prostaglandin D2 + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
1.14.14.1
prostaglandin E1 + [reduced NADPH-hemoprotein reductase] + O2
CYP4A4
660409
Oryctolagus cuniculus
20-hydroxy-prostaglandin E1 + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
1.14.14.1
prostaglandin E2 + [reduced NADPH-hemoprotein reductase] + O2
CYP4A4
660409
Oryctolagus cuniculus
20-hydroxy-prostaglandin E2 + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
1.14.14.1
prostaglandin F2alpha + [reduced NADPH-hemoprotein reductase] + O2
CYP4A4
660409
Oryctolagus cuniculus
20-hydroxy-prostaglandin F2alpha + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
1.14.14.94
(E,Z,Z,Z)-8-hydroxy-5,9,11,14-eicosatetraenoic acid + [reduced NADPH-hemoprotein reductase] + O2
CYP4F2
660409
Homo sapiens
?
-
-
-
?
1.14.14.94
12-hydroxy-5,8,10,14-eicosatetraenoic acid + [reduced NADPH-hemoprotein reductase] + O2
CYP4F2
660409
Homo sapiens
?
-
-
-
?
1.14.14.94
20-hydroxy-leukotriene B4 + [reduced NADPH-hemoprotein reductase] + O2
CYP4F3
660409
Homo sapiens
?
-
-
-
?
1.14.14.94
5-hydroxy-6,8,11,14-eicosatetraenoic acid + [reduced NADPH-hemoprotein reductase] + O2
CYP4F3
660409
Homo sapiens
?
-
-
-
?
1.14.14.94
6-trans-leukotriene B4 + [reduced NADPH-hemoprotein reductase] + O2
CYP4F2
660409
Homo sapiens
?
-
-
-
?
1.14.14.94
6-trans-leukotriene B4 + [reduced NADPH-hemoprotein reductase] + O2
CYP4F3
660409
Homo sapiens
?
-
-
-
?
1.14.14.94
9,11-diazo-15-deoxy-prostaglandin H2 + [reduced NADPH-hemoprotein reductase] + O2
CYP4F8
660409
Homo sapiens
?
-
-
-
?
1.14.14.94
9,11-epoxymethano-prostaglandin H2 + [reduced NADPH-hemoprotein reductase] + O2
CYP4F8
660409
Homo sapiens
?
-
-
-
?
1.14.14.94
arachidonate + [reduced NADPH-hemoprotein reductase] + O2
-
660409
Homo sapiens
20-hydroxy-5,8,11,14-eicosatetraenoic acid + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
1.14.14.94
arachidonate + [reduced NADPH-hemoprotein reductase] + O2
very poor substrate
660409
Homo sapiens
20-hydroxy-5,8,11,14-eicosatetraenoic acid + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
1.14.14.94
arachidonate + [reduced NADPH-hemoprotein reductase] + O2
the enzyme is the principal arachidonate omega-hydroxylase in liver, CYP4F2
660409
Homo sapiens
20-hydroxy-5,8,11,14-eicosatetraenoic acid + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
1.14.14.94
arachidonic acid + [reduced NADPH-hemoprotein reductase] + O2
-
660409
Homo sapiens
18(R)-hydroxyarachidonate + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
1.14.14.94
leukotriene B4 + [reduced NADPH-hemoprotein reductase] + O2
-
660409
Homo sapiens
20-hydroxy-leukotriene B4 + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
1.14.14.94
leukotriene B4 + [reduced NADPH-hemoprotein reductase] + O2
the enzyme plays a critical role in regulating the biological effect of leukotriene B4, CYP4F3
660409
Homo sapiens
20-hydroxy-leukotriene B4 + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
1.14.14.94
leukotriene B4 + [reduced NADPH-hemoprotein reductase] + O2
yielding omega-COOH-leukotriene B4 via omega-hydroxy-leukotriene B4 and omega-CHO-leukotriene B4, CYP4F3
660409
Homo sapiens
20-hydroxy-leukotriene B4 + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
1.14.14.94
lipoxin A4 + [reduced NADPH-hemoprotein reductase] + O2
CYP4F3 preferentially omega-jydroxylates lipoxin B4 over lipoxin A4
660409
Homo sapiens
?
-
-
-
?
1.14.14.94
lipoxin A4 + [reduced NADPH-hemoprotein reductase] + O2
no omega-hydroxylation of LXB4, CYP4F2
660409
Homo sapiens
?
-
-
-
?
1.14.14.94
lipoxin B4 + [reduced NADPH-hemoprotein reductase] + O2
CYP4F3 preferentially omega-jydroxylates lipoxin B4 over lipoxin A4
660409
Homo sapiens
?
-
-
-
?
1.14.14.94
additional information
CYP4F3B and CYP4F2 may function collaboratively as 20-HETE synthetase as well as omega-hydroxylases for leukotiene b4 and other lipoxygenase-dependent eicosanoids in human liver and other tissues
660409
Homo sapiens
?
-
-
-
-
1.14.14.94
prostaglandin H1 + [reduced NADPH-hemoprotein reductase] + O2
CYP4F8
660409
Homo sapiens
19-hydroxy-prostaglandin H1 + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
1.14.14.94
prostaglandin H2 + [reduced NADPH-hemoprotein reductase] + O2
CYP4F8
660409
Homo sapiens
19-hydroxy-prostaglandin H2 + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
Cloned(Commentary) (protein specific)
EC Number
Commentary
Organism
1.14.14.94
expression in yeast; expression in yeast cells, CYP4F3
Homo sapiens
KM Value [mM] (protein specific)
EC Number
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
1.14.14.94
0.00064
-
leukotriene B4
CYP4F3
Homo sapiens
Localization (protein specific)
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
1.14.14.94
microsome
-
Homo sapiens
-
-
Molecular Weight [Da] (protein specific)
EC Number
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
1.14.14.94
additional information
-
the isolated cDNA encodes a protein of 520 amino acids with 59805 Da, CYP4F3
Homo sapiens
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
1.14.14.1
prostaglandin + [reduced NADPH-hemoprotein reductase] + O2
Oryctolagus cuniculus
physiological functions are the metabolic inactivation of prostaglandins and the production of 20-hydroxyeicosatetraenoic acid, CYP4A4
20-hydroxy-prostaglandin + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
?
1.14.14.94
arachidonate + [reduced NADPH-hemoprotein reductase] + O2
Homo sapiens
the enzyme is the principal arachidonate omega-hydroxylase in liver, CYP4F2
20-hydroxy-5,8,11,14-eicosatetraenoic acid + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
?
1.14.14.94
leukotriene B4 + [reduced NADPH-hemoprotein reductase] + O2
Homo sapiens
the enzyme plays a critical role in regulating the biological effect of leukotriene B4, CYP4F3
20-hydroxy-leukotriene B4 + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
?
1.14.14.94
additional information
Homo sapiens
CYP4F3B and CYP4F2 may function collaboratively as 20-HETE synthetase as well as omega-hydroxylases for leukotiene b4 and other lipoxygenase-dependent eicosanoids in human liver and other tissues
?
-
-
-
Purification (Commentary) (protein specific)
EC Number
Commentary
Organism
1.14.14.94
CYP4F3
Homo sapiens
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
1.14.14.1
liver
CYP4A6
Oryctolagus cuniculus
-
1.14.14.1
lung
-
Oryctolagus cuniculus
-
1.14.14.1
small intestine
CYP4A7
Oryctolagus cuniculus
-
1.14.14.94
heart
CYP4F11
Homo sapiens
-
1.14.14.94
ileum
CYP4F3B is the predominant CYP4F isoform
Homo sapiens
-
1.14.14.94
kidney
CYP4F11; CYP4F2; CYP4F3B
Homo sapiens
-
1.14.14.94
liver
CYP4F11; CYP4F2; CYP4F3B is the predominant CYP4F isoform; mRNA for CYP4F8 detected
Homo sapiens
-
1.14.14.94
additional information
CYP4F2 is not expressed in myeloid cells, polymorphonuclear leukocyte; no expression of CYP4F8 in leukocytes
Homo sapiens
-
1.14.14.94
polymorphonuclear leukocyte
CYP4F3 is specifically expressed in. CYP4F3 is restricted to myeloid cells
Homo sapiens
-
1.14.14.94
prostate gland
mRNA for CYP4F8 detected
Homo sapiens
-
1.14.14.94
seminal vesicle
CYP4F8
Homo sapiens
-
1.14.14.94
skeletal muscle
CYP4F11
Homo sapiens
-
1.14.14.94
skin
CYP4F2
Homo sapiens
-
Storage Stability (protein specific)
EC Number
Storage Stability
Organism
1.14.14.94
-70°C, 50% losss of activity after 3 days
Homo sapiens
1.14.14.94
-70°C, no loss of activity with highly purified preparations even after 4 years
Homo sapiens
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1.14.14.1
additional information
no activity with prostaglandins of E type, CYP4A6
660409
Oryctolagus cuniculus
?
-
-
-
-
1.14.14.1
additional information
no activity with prostaglandins of E type, CYP4A7
660409
Oryctolagus cuniculus
?
-
-
-
-
1.14.14.1
prostaglandin + [reduced NADPH-hemoprotein reductase] + O2
physiological functions are the metabolic inactivation of prostaglandins and the production of 20-hydroxyeicosatetraenoic acid, CYP4A4
660409
Oryctolagus cuniculus
20-hydroxy-prostaglandin + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
1.14.14.1
prostaglandin A1 + [reduced NADPH-hemoprotein reductase] + O2
CYP4A4
660409
Oryctolagus cuniculus
20-hydroxy-prostaglandin A1 + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
1.14.14.1
prostaglandin A1 + [reduced NADPH-hemoprotein reductase] + O2
CYP4A6
660409
Oryctolagus cuniculus
20-hydroxy-prostaglandin A1 + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
1.14.14.1
prostaglandin A1 + [reduced NADPH-hemoprotein reductase] + O2
CYP4A7
660409
Oryctolagus cuniculus
20-hydroxy-prostaglandin A1 + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
1.14.14.1
prostaglandin A2 + [reduced NADPH-hemoprotein reductase] + O2
CYP4A4
660409
Oryctolagus cuniculus
20-hydroxy-prostaglandin A2 + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
1.14.14.1
prostaglandin A2 + [reduced NADPH-hemoprotein reductase] + O2
CYP4A6
660409
Oryctolagus cuniculus
20-hydroxy-prostaglandin A2 + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
1.14.14.1
prostaglandin A2 + [reduced NADPH-hemoprotein reductase] + O2
CYP4A7
660409
Oryctolagus cuniculus
20-hydroxy-prostaglandin A2 + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
1.14.14.1
prostaglandin D2 + [reduced NADPH-hemoprotein reductase] + O2
CYP4A4
660409
Oryctolagus cuniculus
20-hydroxy-prostaglandin D2 + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
1.14.14.1
prostaglandin E1 + [reduced NADPH-hemoprotein reductase] + O2
CYP4A4
660409
Oryctolagus cuniculus
20-hydroxy-prostaglandin E1 + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
1.14.14.1
prostaglandin E2 + [reduced NADPH-hemoprotein reductase] + O2
CYP4A4
660409
Oryctolagus cuniculus
20-hydroxy-prostaglandin E2 + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
1.14.14.1
prostaglandin F2alpha + [reduced NADPH-hemoprotein reductase] + O2
CYP4A4
660409
Oryctolagus cuniculus
20-hydroxy-prostaglandin F2alpha + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
1.14.14.94
(E,Z,Z,Z)-8-hydroxy-5,9,11,14-eicosatetraenoic acid + [reduced NADPH-hemoprotein reductase] + O2
CYP4F2
660409
Homo sapiens
?
-
-
-
?
1.14.14.94
12-hydroxy-5,8,10,14-eicosatetraenoic acid + [reduced NADPH-hemoprotein reductase] + O2
CYP4F2
660409
Homo sapiens
?
-
-
-
?
1.14.14.94
20-hydroxy-leukotriene B4 + [reduced NADPH-hemoprotein reductase] + O2
CYP4F3
660409
Homo sapiens
?
-
-
-
?
1.14.14.94
5-hydroxy-6,8,11,14-eicosatetraenoic acid + [reduced NADPH-hemoprotein reductase] + O2
CYP4F3
660409
Homo sapiens
?
-
-
-
?
1.14.14.94
6-trans-leukotriene B4 + [reduced NADPH-hemoprotein reductase] + O2
CYP4F2
660409
Homo sapiens
?
-
-
-
?
1.14.14.94
6-trans-leukotriene B4 + [reduced NADPH-hemoprotein reductase] + O2
CYP4F3
660409
Homo sapiens
?
-
-
-
?
1.14.14.94
9,11-diazo-15-deoxy-prostaglandin H2 + [reduced NADPH-hemoprotein reductase] + O2
CYP4F8
660409
Homo sapiens
?
-
-
-
?
1.14.14.94
9,11-epoxymethano-prostaglandin H2 + [reduced NADPH-hemoprotein reductase] + O2
CYP4F8
660409
Homo sapiens
?
-
-
-
?
1.14.14.94
arachidonate + [reduced NADPH-hemoprotein reductase] + O2
-
660409
Homo sapiens
20-hydroxy-5,8,11,14-eicosatetraenoic acid + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
1.14.14.94
arachidonate + [reduced NADPH-hemoprotein reductase] + O2
very poor substrate
660409
Homo sapiens
20-hydroxy-5,8,11,14-eicosatetraenoic acid + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
1.14.14.94
arachidonate + [reduced NADPH-hemoprotein reductase] + O2
the enzyme is the principal arachidonate omega-hydroxylase in liver, CYP4F2
660409
Homo sapiens
20-hydroxy-5,8,11,14-eicosatetraenoic acid + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
1.14.14.94
arachidonic acid + [reduced NADPH-hemoprotein reductase] + O2
-
660409
Homo sapiens
18(R)-hydroxyarachidonate + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
1.14.14.94
leukotriene B4 + [reduced NADPH-hemoprotein reductase] + O2
-
660409
Homo sapiens
20-hydroxy-leukotriene B4 + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
1.14.14.94
leukotriene B4 + [reduced NADPH-hemoprotein reductase] + O2
the enzyme plays a critical role in regulating the biological effect of leukotriene B4, CYP4F3
660409
Homo sapiens
20-hydroxy-leukotriene B4 + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
1.14.14.94
leukotriene B4 + [reduced NADPH-hemoprotein reductase] + O2
yielding omega-COOH-leukotriene B4 via omega-hydroxy-leukotriene B4 and omega-CHO-leukotriene B4, CYP4F3
660409
Homo sapiens
20-hydroxy-leukotriene B4 + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
1.14.14.94
lipoxin A4 + [reduced NADPH-hemoprotein reductase] + O2
CYP4F3 preferentially omega-jydroxylates lipoxin B4 over lipoxin A4
660409
Homo sapiens
?
-
-
-
?
1.14.14.94
lipoxin A4 + [reduced NADPH-hemoprotein reductase] + O2
no omega-hydroxylation of LXB4, CYP4F2
660409
Homo sapiens
?
-
-
-
?
1.14.14.94
lipoxin B4 + [reduced NADPH-hemoprotein reductase] + O2
CYP4F3 preferentially omega-jydroxylates lipoxin B4 over lipoxin A4
660409
Homo sapiens
?
-
-
-
?
1.14.14.94
additional information
CYP4F3B and CYP4F2 may function collaboratively as 20-HETE synthetase as well as omega-hydroxylases for leukotiene b4 and other lipoxygenase-dependent eicosanoids in human liver and other tissues
660409
Homo sapiens
?
-
-
-
-
1.14.14.94
prostaglandin H1 + [reduced NADPH-hemoprotein reductase] + O2
CYP4F8
660409
Homo sapiens
19-hydroxy-prostaglandin H1 + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
1.14.14.94
prostaglandin H2 + [reduced NADPH-hemoprotein reductase] + O2
CYP4F8
660409
Homo sapiens
19-hydroxy-prostaglandin H2 + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?