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Literature summary extracted from

  • Kantorow, M.; Hawse, J.R.; Cowell, T.L.; Benhamed, S.; Pizarro, G.O.; Reddy, V.N.; Hejtmancik, J.F.
    Methionine sulfoxide reductase A is important for lens cell viability and resistance to oxidative stress (2004), Proc. Natl. Acad. Sci. USA, 101, 9654-9659.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.8.4.11 overexpression of msrA gene in HLE cells protects against oxidative stress, while silencing of the gene by short interfering RNA-targeted gene silencing method renders the lens epithelial cells more sensitive to oxidative stress damage Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.8.4.11 L-methionine (S)-sulfoxide + thioredoxin Homo sapiens oxidation of protein-bound methionine results in loss of protein function, but can be reversed by the enzyme activity reducing methionine sulfoxide L-methionine + thioredoxin disulfide + H2O
-
 ?
1.8.4.11 additional information Homo sapiens the enzyme is an essential regulator of longevity and is important for lens cell viability and resistance to oxidative stress, methionine sulfoxide is the major oxidative stress product, up to 60%, in cataract while being essentially absent in clear lens ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.8.4.11 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.8.4.11 epithelium lens Homo sapiens
-
1.8.4.11 hepatoma HLE cell human lens epithelial cell line Homo sapiens
-
1.8.4.11 lens
-
 Homo sapiens
-
1.8.4.11 lens fiber cortical and nuclear components Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.8.4.11 L-methionine (S)-sulfoxide + thioredoxin
-
 Homo sapiens L-methionine + thioredoxin disulfide + H2O
-
 ?
1.8.4.11 L-methionine (S)-sulfoxide + thioredoxin oxidation of protein-bound methionine results in loss of protein function, but can be reversed by the enzyme activity reducing methionine sulfoxide Homo sapiens L-methionine + thioredoxin disulfide + H2O
-
 ?
1.8.4.11 additional information the enzyme is an essential regulator of longevity and is important for lens cell viability and resistance to oxidative stress, methionine sulfoxide is the major oxidative stress product, up to 60%, in cataract while being essentially absent in clear lens Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.8.4.11 methionine sulfoxide reductase A
-
 Homo sapiens
1.8.4.11 MsrA
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.8.4.11 thioredoxin
-
 Homo sapiens