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Literature summary extracted from

  • Romero, H.M.; Berlett, B.S.; Jensen, P.J.; Pell, E.J.; Tien, M.
    Investigations into the role of the plastidial peptide methionine sulfoxide reductase in response to oxidative stress in Arabidopsis (2004), Plant Physiol., 136, 3784-3794.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.8.4.11 additional information effects of high light, ozone, and paraquat on enzyme activity and photosynthetic activity in wild-type and transgenic plants, overview Arabidopsis thaliana

Protein Variants

EC Number Protein Variants Comment Organism
1.8.4.11 additional information construction of several transgenic plant lines with altered expression level of the plastidic isozyme PMSR4 of 40-600% compared to wild-type expression level, which results in no phenotype under optimal growing conditions, but at oxidative stress conditions differences in the photosynthesis rate, and the rate of oxidized methionine residues in the chloroplast occur, overexpressing plants are more resistant to oxidative stress, while antisense plants show increased sensitivity, expression analysis Arabidopsis thaliana

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.8.4.11 additional information effects of high light, ozone, and paraquat on enzyme activity and photosynthetic activity in wild-type and transgenic plants, overview Arabidopsis thaliana

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.8.4.11 chloroplast plastidial isozyme PMSR4, soluble fraction Arabidopsis thaliana 9507
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.8.4.11 protein-L-methionine (S)-sulfoxide + thioredoxin Arabidopsis thaliana enzyme provides protection against oxidative damage by reactive oxygen species and has a repair function for oxidized protein methionine residues protein-L-methionine + thioredoxin disulfide + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.8.4.11 Arabidopsis thaliana P54150 ecotype Columbia
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.8.4.11 purification of chloroplasts from wild-type and transgenic plants Arabidopsis thaliana

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.8.4.11 additional information
-
 relative activity in chloroplasts of wild-type and transgenic plants Arabidopsis thaliana

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.8.4.11 Fmoc-L-methionine (S)-sulfoxide + dithiothreitol
-
 Arabidopsis thaliana Fmoc-L-methionine + dithiothreitol disulfide + H2O
-
 ?
1.8.4.11 protein-L-methionine (S)-sulfoxide + thioredoxin
-
 Arabidopsis thaliana protein-L-methionine + thioredoxin disulfide + H2O
-
 ?
1.8.4.11 protein-L-methionine (S)-sulfoxide + thioredoxin enzyme provides protection against oxidative damage by reactive oxygen species and has a repair function for oxidized protein methionine residues Arabidopsis thaliana protein-L-methionine + thioredoxin disulfide + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.8.4.11 peptide methionine sulfoxide reductase
-
 Arabidopsis thaliana
1.8.4.11 PMSR
-
 Arabidopsis thaliana

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.8.4.11 8
-
 assay at Arabidopsis thaliana

Cofactor

EC Number Cofactor Comment Organism Structure
1.8.4.11 dithiothreitol
-
 Arabidopsis thaliana
1.8.4.11 thioredoxin
-
 Arabidopsis thaliana