Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Esteller, M.; Herman, J.G.
    Generating mutations but providing chemosensitivity: the role of O6-methylguanine DNA methyltransferase in human cancer (2004), Oncogene, 23, 1-8.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.63 DNA containing 6-O-methylguanine + [protein]-L-cysteine Homo sapiens key enzyme in DNA repair network. Hypermethylation of the CpG island located in the promoter region of MGMT is primarily responsible for the loss of enzyme function in many tumor types. The methylation mediated silencing of MGMT has two consequences for cancer. First, tumors with MGMT methylation have a new mutator phenotype characterized by the generation of transition point mutations in genes involved in cancer etiology, such as the tumor suppressor p53 and the oncogene K-ras. Second, MGMT hypermethylation demonstrates the possibility of pharmacoepigenomics: methylated tumors are more sensitive to the killing effects of alkylating drugs used in chemotherapy DNA lacking 6-O-methylguanine + [protein]-S-methyl-L-cysteine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.63 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.63 DNA containing 6-O-methylguanine + [protein]-L-cysteine key enzyme in DNA repair network. Hypermethylation of the CpG island located in the promoter region of MGMT is primarily responsible for the loss of enzyme function in many tumor types. The methylation mediated silencing of MGMT has two consequences for cancer. First, tumors with MGMT methylation have a new mutator phenotype characterized by the generation of transition point mutations in genes involved in cancer etiology, such as the tumor suppressor p53 and the oncogene K-ras. Second, MGMT hypermethylation demonstrates the possibility of pharmacoepigenomics: methylated tumors are more sensitive to the killing effects of alkylating drugs used in chemotherapy Homo sapiens DNA lacking 6-O-methylguanine + [protein]-S-methyl-L-cysteine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.1.1.63 MGMT
-
 Homo sapiens
2.1.1.63 O6-methylguanine DNA methyltransferase
-
 Homo sapiens