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Literature summary extracted from
- Cloning and analysis of Trypanosoma cruzi lanosterol 14alpha-demethylase (2003), Mol. Biochem. Parasitol., 132, 75-81.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 1.14.14.154 | expression of gene during both insect and mammalian life-cycle stage | Trypanosoma cruzi |
Protein Variants
| EC Number | Protein Variants | Comment | Organism |
|---|---|---|---|
| 1.14.14.154 | additional information | enzyme is able to complement the function of the homologous gene in yeast | Trypanosoma cruzi |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 1.14.14.154 | 52000 | - |
x * 52000, SDS-PAGE, recombinant enzyme | Trypanosoma cruzi |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.14.14.154 | Trypanosoma cruzi | - |
- |
- |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.14.154 | lanosterol + [reduced NADPH-hemoprotein reductase] + O2 | - |
Trypanosoma cruzi | 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? |  |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 1.14.14.154 | ? | x * 52000, SDS-PAGE, recombinant enzyme | Trypanosoma cruzi |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.14.154 | cytochrome P450 | - |
Trypanosoma cruzi |
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Release 2023.1 (January 2023)
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