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Literature summary extracted from

  • Zambianchi, F.; Raimondi, S.; Pasta, P.; Carrea, G.; Gaggero, N.; Woodley, J.M.
    Comparison of cyclohexanone monooxygenase as an isolated enzyme and whole cell biocatalyst for the enantioselective oxidation of 1,3-dithiane (2004), J. Mol. Catal. B, 31, 165-171.
No PubMed abstract available

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.14.13.22 expressed in Escherichia coli TOP10 Acinetobacter calcoaceticus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.13.22 1,3-dithiane substrate inhibition Acinetobacter calcoaceticus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.14.13.22 0.045
-
1,3-dithiane pH 8.6, 25°C Acinetobacter calcoaceticus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.13.22 cyclohexanone + NADPH + O2 Acinetobacter calcoaceticus
-
hexano-6-lactone + NADP+ + H2O
-
?
1.14.13.22 cyclohexanone + NADPH + O2 Acinetobacter calcoaceticus NCIMB 9871
-
hexano-6-lactone + NADP+ + H2O
-
?

Organism

EC Number Organism UniProt Comment Textmining
1.14.13.22 Acinetobacter calcoaceticus
-
NCIMB 9871
-
1.14.13.22 Acinetobacter calcoaceticus NCIMB 9871
-
NCIMB 9871
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.14.13.22 partial purification of recombinant enzyme Acinetobacter calcoaceticus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.13.22 1,3-dithiane + NADPH + O2
-
Acinetobacter calcoaceticus (R)-1,3-dithiane-1-oxide + NADP+ + H2O
-
?
1.14.13.22 1,3-dithiane + NADPH + O2
-
Acinetobacter calcoaceticus NCIMB 9871 (R)-1,3-dithiane-1-oxide + NADP+ + H2O
-
?
1.14.13.22 cyclohexanone + NADPH + O2
-
Acinetobacter calcoaceticus hexano-6-lactone + NADP+ + H2O
-
?
1.14.13.22 cyclohexanone + NADPH + O2
-
Acinetobacter calcoaceticus NCIMB 9871 hexano-6-lactone + NADP+ + H2O
-
?

Synonyms

EC Number Synonyms Comment Organism
1.14.13.22 cyclohexanone:NADPH:oxygen oxidoreductase (lactone-forming)
-
Acinetobacter calcoaceticus

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.13.22 NADPH
-
Acinetobacter calcoaceticus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.14.13.22 15
-
1,3-dithiane pH 8.6, 25°C Acinetobacter calcoaceticus