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Literature summary extracted from

  • Musayev, F.; Sachdeva, S.; Scarsdale, J.N.; Reynolds, K.A.; Wright, H.T.
    Crystal structure of a substrate complex of Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthase III (FabH) with lauroyl-coenzyme A (2005), J. Mol. Biol., 346, 1313-1321.
    View publication on PubMed

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
2.3.1.41 in complex with lauroyl-CoA Mycobacterium tuberculosis
2.3.1.180 purified recombinant enzyme in complex with lauroyl-CoA, X-ray diffraction structure determination and analysis at 1.85-2.3 A resolution, modeling Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.180 acetyl-CoA + malonyl-[acyl-carrier protein] Mycobacterium tuberculosis the enzyme initiates the fatty acid biosynthesis acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
 ?
2.3.1.180 acetyl-CoA + malonyl-[acyl-carrier protein] Mycobacterium tuberculosis H37Rv the enzyme initiates the fatty acid biosynthesis acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.41 Mycobacterium tuberculosis
-
-
-
2.3.1.180 Mycobacterium tuberculosis P9WNG3
-
-
2.3.1.180 Mycobacterium tuberculosis H37Rv P9WNG3
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
2.3.1.180 acetyl-CoA + a malonyl-[acyl-carrier protein] = an acetoacetyl-[acyl-carrier protein] + CoA + CO2 catalytic reaction mechanism for decarboxylation and condensation Mycobacterium tuberculosis
a

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.41 malonyl-[acyl-carrier protein] + lauroyl-CoA
-
 Mycobacterium tuberculosis ? + CO2 + [acyl-carrier protein]
-
 ?
2.3.1.41 malonyl-[acyl-carrier protein] + myristoyl-CoA
-
 Mycobacterium tuberculosis ? + CO2 + [acyl-carrier protein]
-
 ?
2.3.1.41 malonyl-[acyl-carrier protein] + palmitoyl-CoA
-
 Mycobacterium tuberculosis ? + CO2 + [acyl-carrier protein]
-
 ?
2.3.1.180 acetyl-CoA + malonyl-[acyl-carrier protein]
-
 Mycobacterium tuberculosis acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
 ?
2.3.1.180 acetyl-CoA + malonyl-[acyl-carrier protein] the enzyme initiates the fatty acid biosynthesis Mycobacterium tuberculosis acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
 ?
2.3.1.180 acetyl-CoA + malonyl-[acyl-carrier protein]
-
 Mycobacterium tuberculosis H37Rv acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
 ?
2.3.1.180 acetyl-CoA + malonyl-[acyl-carrier protein] the enzyme initiates the fatty acid biosynthesis Mycobacterium tuberculosis H37Rv acetoacetyl-[acyl-carrier protein] + CoA + CO2
-
 ?
2.3.1.180 lauroyl-CoA + malonyl-[acyl-carrier protein] the primer substrate lauroyl-CoA is bound to subunit A, binding structure, lauroyl is bound in a channel Mycobacterium tuberculosis 3-oxo-myristoyl-[acyl-carrier protein] + CoA + CO2
-
 ?
2.3.1.180 lauroyl-CoA + malonyl-[acyl-carrier protein] the primer substrate lauroyl-CoA is bound to subunit A, binding structure, lauroyl is bound in a channel Mycobacterium tuberculosis H37Rv 3-oxo-myristoyl-[acyl-carrier protein] + CoA + CO2
-
 ?

Subunits

EC Number Subunits Comment Organism
2.3.1.180 dimer dimer packing analysis from crystal structure Mycobacterium tuberculosis

Synonyms

EC Number Synonyms Comment Organism
2.3.1.180 beta-ketoacyl-acyl carrier protein synthase III
-
 Mycobacterium tuberculosis
2.3.1.180 FabH
-
 Mycobacterium tuberculosis