Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Li, C.; Xu, L.; Wolan, D.W.; Wilson, I.A.; Olson, A.J.
    Virtual screening of human 5-aminoimidazole-4-carboxamide ribonucleotide transformylase against the NCI diversity set by use of AutoDock to identify novel nonfolate inhibitors (2004), J. Med. Chem., 47, 6681-6690.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.1.2.3 medicine potential target for antineoplastic drug design Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.2.3 NSC126445 IC50: 0.010mM Homo sapiens
2.1.2.3 NSC170645 IC50: 0.036 mM Homo sapiens
2.1.2.3 NSC26699 IC50: 0.017 mM Homo sapiens
2.1.2.3 NSC292213 IC50: 0.009 mM Homo sapiens
2.1.2.3 NSC30171 IC50: 0.0006 mM Homo sapiens
2.1.2.3 NSC321237 IC50: 0.106 mM Homo sapiens
2.1.2.3 NSC324571 IC50: 0.020 mM Homo sapiens
2.1.2.3 NSC324572 IC50: 0.012 mM Homo sapiens
2.1.2.3 NSC324981 IC50: 0.020 mM Homo sapiens
2.1.2.3 NSC326203 IC50: 0.012 mM Homo sapiens
2.1.2.3 NSC326211 IC50: 0.204 mM Homo sapiens
2.1.2.3 NSC37031 IC50: 0.008 mM Homo sapiens
2.1.2.3 NSC37173 IC50: 0.004 mM Homo sapiens
2.1.2.3 NSC41806 IC50: 0.055 mM Homo sapiens
2.1.2.3 NSC45592 IC50: 0.012 mM Homo sapiens
2.1.2.3 NSC47729 IC50: 0.003 mM Homo sapiens
2.1.2.3 NSC58046 IC50: 0.008 mM Homo sapiens
2.1.2.3 NSC7524 IC50: 0.231 mM Homo sapiens
2.1.2.3 NSC88915 IC50: 0.014 mM Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.2.3 10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazole-4-carboxamide Homo sapiens penultimate step of the purine de novo synthesis pathway tetrahydrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazole-4-carboxamide
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.2.3 Homo sapiens P31939
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.2.3 10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazole-4-carboxamide
-
 Homo sapiens tetrahydrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazole-4-carboxamide
-
 ?
2.1.2.3 10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazole-4-carboxamide penultimate step of the purine de novo synthesis pathway Homo sapiens tetrahydrofolic acid + 5'-phosphoribosyl-5-formamido-4-imidazole-4-carboxamide
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.1.2.3 AICAR transformylase/inosine monophosphate cyclohydrolase bifunctional enzyme catalyzing the last two steps of the purine de novo synthesis pathway Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.1.2.3 10-formyltetrahydrofolate
-
 Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.1.2.3 0.000015
-
 NSC30171
-
 Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.1.2.3 0.0006
-
 IC50: 0.0006 mM Homo sapiens NSC30171
2.1.2.3 0.003
-
 IC50: 0.003 mM Homo sapiens NSC47729
2.1.2.3 0.004
-
 IC50: 0.004 mM Homo sapiens NSC37173
2.1.2.3 0.008
-
 IC50: 0.008 mM Homo sapiens NSC37031
2.1.2.3 0.008
-
 IC50: 0.008 mM Homo sapiens NSC58046
2.1.2.3 0.009
-
 IC50: 0.009 mM Homo sapiens NSC292213
2.1.2.3 0.01
-
 IC50: 0.010mM Homo sapiens NSC126445
2.1.2.3 0.012
-
 IC50: 0.012 mM Homo sapiens NSC326203
2.1.2.3 0.012
-
 IC50: 0.012 mM Homo sapiens NSC45592
2.1.2.3 0.012
-
 IC50: 0.012 mM Homo sapiens NSC324572
2.1.2.3 0.014
-
 IC50: 0.014 mM Homo sapiens NSC88915
2.1.2.3 0.017
-
 IC50: 0.017 mM Homo sapiens NSC26699
2.1.2.3 0.02
-
 IC50: 0.020 mM Homo sapiens NSC324981
2.1.2.3 0.02
-
 IC50: 0.020 mM Homo sapiens NSC324571
2.1.2.3 0.036
-
 IC50: 0.036 mM Homo sapiens NSC170645
2.1.2.3 0.055
-
 IC50: 0.055 mM Homo sapiens NSC41806
2.1.2.3 0.106
-
 IC50: 0.106 mM Homo sapiens NSC321237
2.1.2.3 0.204
-
 IC50: 0.204 mM Homo sapiens NSC326211
2.1.2.3 0.231
-
 IC50: 0.231 mM Homo sapiens NSC7524