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Literature summary extracted from

  • Erat, M.; Sakiroglu, H.; Ciftci, M.
    Effects of some antibiotics on glutathione reductase activities from human erythrocytes in vitro and from rat erythrocytes in vivo (2005), J. Enzyme Inhib. Med. Chem., 20, 69-74.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.8.1.7 ampicillin leads to slight activation in vivo Rattus norvegicus
1.8.1.7 gentamycin sulfate leads to slight activation in vivo Rattus norvegicus
1.8.1.7 penicillin G leads to slight activation in vivo Rattus norvegicus
1.8.1.7 streptomycin sulfate leads to slight activation in vivo Rattus norvegicus
1.8.1.7 teicoplanin leads to slight activation in vivo Rattus norvegicus
1.8.1.7 Thiamphenicol leads to slight activation in vivo Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.8.1.7 cefodizime competitive inhibition, in vitro Homo sapiens
1.8.1.7 cefodizime competitive, 21% inhibition in vivo, effect decreases with time Rattus norvegicus
1.8.1.7 cefotaxime noncompetitive inhibition, in vitro Homo sapiens
1.8.1.7 cefotaxime noncompetitive, 46% inhibition in vivo, effect decreases with time Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.8.1.7 glutathione disulfide + NADPH Homo sapiens
-
 glutathione + NADP+
-
 ?
1.8.1.7 glutathione disulfide + NADPH Rattus norvegicus
-
 glutathione + NADP+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.8.1.7 Homo sapiens
-
-
-
1.8.1.7 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.8.1.7 5342fold to homogeneity from erythrocytes by hemolysis, ammonium sulfate fractionation, affinity chromatography, and gel filtration Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.8.1.7 erythrocyte
-
 Homo sapiens
-
1.8.1.7 erythrocyte
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.8.1.7 50.75
-
 purified erythrocyte enzyme Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.8.1.7 glutathione disulfide + NADPH
-
 Homo sapiens glutathione + NADP+
-
 ?
1.8.1.7 glutathione disulfide + NADPH
-
 Rattus norvegicus glutathione + NADP+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.8.1.7 glutathione reductase
-
 Homo sapiens
1.8.1.7 glutathione reductase
-
 Rattus norvegicus
1.8.1.7 GR
-
 Homo sapiens
1.8.1.7 GR
-
 Rattus norvegicus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.8.1.7 25
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.8.1.7 8
-
 assay at Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.8.1.7 NADPH
-
 Homo sapiens
1.8.1.7 NADPH
-
 Rattus norvegicus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.8.1.7 0.745
-
 cefodizime pH 8.0, 25°C Homo sapiens
1.8.1.7 6.51
-
 cefotaxime pH 8.0, 25°C Homo sapiens