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Literature summary extracted from

  • Matsuura, K.; Yoshioka, S.; Tosha, T.; Hori, H.; Ishimori, K.; Kitagawa, T.; Morishima, I.; Kagawa, N.; Waterman, M.R.
    Structural diversities of active site in clinical azole-bound forms between sterol 14alpha-demethylases (CYP51s) from human and Mycobacterium tuberculosis (2005), J. Biol. Chem., 280, 9088-9096.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.14.154 2-phenylimidazole Kd-value 9.1 mM, comparison of affinity and binding to human and Mycobacterium tuberculosis enzyme Homo sapiens
1.14.14.154 2-phenylimidazole Kd-value 2.1 mM, comparison of affinity and binding to human and Mycobacterium tuberculosis enzyme Mycobacterium tuberculosis
1.14.14.154 4-phenylimidazole Kd-value 0.19 mM, comparison of affinity and binding to human and Mycobacterium tuberculosis enzyme Homo sapiens
1.14.14.154 4-phenylimidazole Kd-value 0.29 mM, comparison of affinity and binding to human and Mycobacterium tuberculosis enzyme Mycobacterium tuberculosis
1.14.14.154 fluconazole Kd-value 0.12 mM, comparison of affinity and binding to human and Mycobacterium tuberculosis enzyme Homo sapiens
1.14.14.154 fluconazole Kd-value 0.02 mM, comparison of affinity and binding to human and Mycobacterium tuberculosis enzyme Mycobacterium tuberculosis
1.14.14.154 ketoconazole Kd-value 0.008 mM, comparison of affinity and binding to human and Mycobacterium tuberculosis enzyme Homo sapiens
1.14.14.154 ketoconazole Kd-value 0.019 mM, comparison of affinity and binding to human and Mycobacterium tuberculosis enzyme Mycobacterium tuberculosis

Organism

EC Number Organism UniProt Comment Textmining
1.14.14.154 Homo sapiens
-
-
-
1.14.14.154 Mycobacterium tuberculosis P9WPP9
-
-
1.14.14.154 Mycobacterium tuberculosis H37Rv P9WPP9
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.14.154 additional information analysis of active site by spectroscopic titration, resonance Raman spectroscopy and EPR Mycobacterium tuberculosis ?
-
 ?
1.14.14.154 additional information analysis of active site by stectroscopic titration, resonance Raman spectroscopy and EPR Homo sapiens ?
-
 ?
1.14.14.154 additional information analysis of active site by spectroscopic titration, resonance Raman spectroscopy and EPR Mycobacterium tuberculosis H37Rv ?
-
 ?