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Literature summary extracted from

  • Birgander, P.L.; Bug, S.; Kasrayan, A.; Dahlroth, S.L.; Westman, M.; Gordon, E.; Sjoberg, B.M.
    Nucleotide-dependent formation of catalytically competent dimers from engineered monomeric ribonucleotide reductase protein R1 (2005), J. Biol. Chem., 280, 14997-15003.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
1.17.4.1 N238A the monomeric R1 protein is able to dimerize when bound by both substrate and effector and is able to reduce ribonucleotides with a comparatively high capacity Escherichia coli

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.17.4.1 additional information Escherichia coli each catalytic turnover by aerobic ribonucleotide reductase requires the assembly of the two proteins, R1 (alpha2) and R2 (beta2), to produce deoxyribonucleotides for DNA synthesis ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.17.4.1 Escherichia coli
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.17.4.1 CDP + reduced thioredoxin
-
 Escherichia coli 2'-dCDP + thioredoxin disulfide + H2O
-
 ?
1.17.4.1 CTP + reduced thioredoxin
-
 Escherichia coli 2'-dCTP + thioredoxin disulfide + H2O
-
 ?
1.17.4.1 additional information each catalytic turnover by aerobic ribonucleotide reductase requires the assembly of the two proteins, R1 (alpha2) and R2 (beta2), to produce deoxyribonucleotides for DNA synthesis Escherichia coli ?
-
 ?

Subunits

EC Number Subunits Comment Organism
1.17.4.1 More each catalytic turnover by aerobic ribonucleotide reductase requires the assembly of the two proteins, R1 (alpha2) and R2 (beta2), to produce deoxyribonucleotides for DNA synthesis Escherichia coli

Synonyms

EC Number Synonyms Comment Organism
1.17.4.1 ribonucleotide reductase
-
 Escherichia coli

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.17.4.1 additional information
-
 additional information turnover number of wild-type and mutant proteins of R1 protein Escherichia coli