EC Number | Cloned (Comment) | Organism |
---|---|---|
2.3.1.39 | DNA and amino acid sequence determination and analysis, phylogenetic tree, expression as GFP-fusion protein containing the mitochondrial targeting sequence in mitochondria of HeLa cells, expression of truncated enzyme forms lacking the first 21 or 59 amino acid residues, respectively, in Escherichia coli strain BL21(DE3) as soluble enzymes, or in Spodoptera frugiperda Sf9 cells via baculovirus infection system | Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.3.1.41 | cerulenin | 50% inhibition at 0.2 mM | Homo sapiens |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.3.1.41 | 0.0018 | - |
decanoyl-[acyl-carrier protein] | pH 6.8, 37°C | Homo sapiens | |
2.3.1.41 | 0.0019 | - |
hexanoyl-[acyl-carrier protein] | pH 6.8, 37°C | Homo sapiens | |
2.3.1.41 | 0.0039 | - |
butanoyl-[acyl-carrier protein] | pH 6.8, 37°C | Homo sapiens | |
2.3.1.41 | 0.0095 | - |
dodecanoyl-[acyl-carrier protein] | pH 6.8, 37°C | Homo sapiens | |
2.3.1.41 | 0.0109 | - |
octanoyl-[acyl-carrier protein] | pH 6.8, 37°C | Homo sapiens | |
2.3.1.41 | 0.05 | - |
acetyl-[acyl-carrier protein] | pH 6.8, 37°C | Homo sapiens | |
2.3.1.41 | 0.0508 | - |
myristoyl-[acyl-carrier protein] | pH 6.8, 37°C | Homo sapiens |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
2.3.1.39 | mitochondrion | enzyme is part of the malonyl-CoA-dependent type II fatty acid synthase complex in mitochondria, and contains a mitochondrial targeting sequence | Homo sapiens | 5739 | - |
2.3.1.41 | mitochondrion | - |
Homo sapiens | 5739 | - |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
2.3.1.41 | 45800 | - |
x * 45800, SDS-PAGE, recombinant protein without N-terminal targeting sequence, with His-tag | Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.3.1.39 | malonyl-CoA + [acyl-carrier protein] | Homo sapiens | absolutely specific for the substrates, type II [acyl-carrier protein] | CoA + malonyl-[acyl-carrier protein] | - |
? | |
2.3.1.39 | additional information | Homo sapiens | enzyme is part of the malonyl-CoA-dependent type II fatty acid synthase complex in mitochondria | ? | - |
? | |
2.3.1.41 | additional information | Homo sapiens | important role in generation of the lipoic acid precursor octanoyl-acyl-carrier protein | ? | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.3.1.39 | Homo sapiens | - |
- |
- |
2.3.1.41 | Homo sapiens | - |
expression in Escherichia coli, without N-terminal targeting sequence | - |
EC Number | Posttranslational Modification | Comment | Organism |
---|---|---|---|
2.3.1.41 | proteolytic modification | mitochondrial targeting sequence of 38 residues | Homo sapiens |
EC Number | Purification (Comment) | Organism |
---|---|---|
2.3.1.39 | recombinant truncated enzyme forms from Sf9 insect cells | Homo sapiens |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.3.1.41 | brain | low level | Homo sapiens | - |
2.3.1.41 | heart | most abundant | Homo sapiens | - |
2.3.1.41 | kidney | - |
Homo sapiens | - |
2.3.1.41 | liver | - |
Homo sapiens | - |
2.3.1.41 | lung | low level | Homo sapiens | - |
2.3.1.41 | placenta | low level | Homo sapiens | - |
2.3.1.41 | skeletal muscle | most abundant | Homo sapiens | - |
2.3.1.41 | spleen | low level | Homo sapiens | - |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
2.3.1.39 | 0.1 | - |
recombinant enzyme with recombinant ACP-A from Bacillus subtilis | Homo sapiens |
2.3.1.39 | 0.14 | - |
recombinant enzyme with recombinant human mitochondrial [acyl-carrier protein] lacking the first 68 amino acid residues | Homo sapiens |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.3.1.39 | malonyl-CoA + [acyl-carrier protein] | absolutely specific for the substrates, type II [acyl-carrier protein] | Homo sapiens | CoA + malonyl-[acyl-carrier protein] | - |
? | |
2.3.1.39 | malonyl-CoA + [acyl-carrier protein] | absolutely specific for the substrates, recombinant type II [acyl-carrier protein] lacking the N-terminal 68 amino acid residues from human, or recombinant ACP-A from Bacillus subtilis | Homo sapiens | CoA + malonyl-[acyl-carrier protein] | - |
? | |
2.3.1.39 | additional information | enzyme is part of the malonyl-CoA-dependent type II fatty acid synthase complex in mitochondria | Homo sapiens | ? | - |
? | |
2.3.1.41 | acetyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] | - |
Homo sapiens | 3-oxobutanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein] | - |
? | |
2.3.1.41 | butanoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] | - |
Homo sapiens | 3-oxohexanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein] | - |
? | |
2.3.1.41 | decanoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] | - |
Homo sapiens | dodecanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein] | - |
? | |
2.3.1.41 | dodecanoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] | - |
Homo sapiens | 3-oxotetradecanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein] | - |
? | |
2.3.1.41 | hexanoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] | - |
Homo sapiens | 3-oxooctanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein] | - |
? | |
2.3.1.41 | additional information | important role in generation of the lipoic acid precursor octanoyl-acyl-carrier protein | Homo sapiens | ? | - |
? | |
2.3.1.41 | additional information | preference for acyl-[acyl-carrier protein] in decreasing order: C12, C10, C6, C8, C4, C2, C14, C16 | Homo sapiens | ? | - |
? | |
2.3.1.41 | myristoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] | - |
Homo sapiens | 3-oxohexadecanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein] | - |
? | |
2.3.1.41 | octanoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] | - |
Homo sapiens | 3-oxodecanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein] | - |
? | |
2.3.1.41 | palmitoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] | - |
Homo sapiens | 3-oxooctadecanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein] | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
2.3.1.41 | ? | x * 45800, SDS-PAGE, recombinant protein without N-terminal targeting sequence, with His-tag | Homo sapiens |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
2.3.1.39 | 20 | - |
assay at | Homo sapiens |
EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.3.1.41 | 6 | - |
myristoyl-[acyl-carrier protein] | pH 6.8, 37°C | Homo sapiens | |
2.3.1.41 | 66 | - |
octanoyl-[acyl-carrier protein] | pH 6.8, 37°C | Homo sapiens | |
2.3.1.41 | 91.2 | - |
butanoyl-[acyl-carrier protein] | pH 6.8, 37°C | Homo sapiens | |
2.3.1.41 | 303 | - |
dodecanoyl-[acyl-carrier protein] | pH 6.8, 37°C | Homo sapiens | |
2.3.1.41 | 353 | - |
hexanoyl-[acyl-carrier protein] | pH 6.8, 37°C | Homo sapiens | |
2.3.1.41 | 551 | - |
decanoyl-[acyl-carrier protein] | pH 6.8, 37°C | Homo sapiens |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
2.3.1.39 | 6.8 | - |
assay at | Homo sapiens |