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Literature summary extracted from

  • Evans, J.P.; Ahn, K.; Klinman, J.P.
    Evidence that dioxygen and substrate activation are tightly coupled in dopamine beta-monooxygenase: Implications for the reactive oxygen species (2003), J. Biol. Chem., 278, 49691-49698.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.17.1 beta,beta-difluorophenethylamine weak competitive inhibitor Bos taurus

Organism

EC Number Organism UniProt Comment Textmining
1.14.17.1 Bos taurus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.17.1 adrenal gland
-
 Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.17.1 dopamine + ascorbate + O2
-
 Bos taurus noradrenaline + dehydroascorbate + H2O
-
 ?
1.14.17.1 additional information evidence that dioxygen and substrate activation are tightly coupled in dopamine beta-monooxygenase Bos taurus ?
-
 ?
1.14.17.1 phenylethylamine + ascorbate + O2
-
 Bos taurus ? + dehydroascorbate + H2O
-
 ?
1.14.17.1 tyramine + ascorbate + O2
-
 Bos taurus octopamine + dehydroascorbate + H2O
-
 ?

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.14.17.1 26
-
 beta,beta-difluorophenethylamine pH 6.0, 35°C Bos taurus