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Literature summary extracted from

  • Reuter, G.; Janvilisri, T.; Venter, H.; Shahi, S.; Balakrishnan, L.; van Veen, H.W.
    The ATP binding cassette multidrug transporter LmrA and lipid transporter MsbA have overlapping substrate specificities (2003), J. Biol. Chem., 278, 35193-35198.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
7.6.2.2 lipid A stimulates ATPase activity Lactococcus lactis

Cloned(Commentary)

EC Number Cloned (Comment) Organism
7.6.2.2 lmrA gene, expression in Escherichia coli WD2 Lactococcus lactis

Inhibitors

EC Number Inhibitors Comment Organism Structure
7.6.2.2 vanadate vanadate-sensitive ATPase activity Lactococcus lactis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
7.6.2.2 additional information Lactococcus lactis possible role for LmrA in lipid trafficking ?
-
 ?
7.6.2.2 additional information Lactococcus lactis NZ9000 possible role for LmrA in lipid trafficking ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
7.6.2.2 Lactococcus lactis
-
-
-
7.6.2.2 Lactococcus lactis NZ9000
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.6.2.2 ATP + H2O + 2'-(4-ethoxyphenyl)-5-(4-methyl-1-piperazinyl)-2,5'-bis-1H-benzimidazole/in Hoechst 33342 Lactococcus lactis ADP + phosphate + 2'-(4-ethoxyphenyl)-5-(4-methyl-1-piperazinyl)-2,5'-bis-1H-benzimidazole/out
-
 ?
7.6.2.2 ATP + H2O + 2'-(4-ethoxyphenyl)-5-(4-methyl-1-piperazinyl)-2,5'-bis-1H-benzimidazole/in Hoechst 33342 Lactococcus lactis NZ9000 ADP + phosphate + 2'-(4-ethoxyphenyl)-5-(4-methyl-1-piperazinyl)-2,5'-bis-1H-benzimidazole/out
-
 ?
7.6.2.2 ATP + H2O + daunomycin/in
-
 Lactococcus lactis ADP + phosphate + daunomycin/out
-
 ?
7.6.2.2 ATP + H2O + daunomycin/in
-
 Lactococcus lactis NZ9000 ADP + phosphate + daunomycin/out
-
 ?
7.6.2.2 ATP + H2O + ethidium bromide/in recombinant LmrA, expressed in Escherichia coli WD2 Lactococcus lactis ADP + phosphate + ethidium bromide/out
-
 ?
7.6.2.2 ATP + H2O + Lipid A/in native LmrA Lactococcus lactis ADP + phosphate + Lipid A/out
-
 ?
7.6.2.2 ATP + H2O + vinblastine/in
-
 Lactococcus lactis ADP + phosphate + vinblastine/out
-
 ?
7.6.2.2 ATP + H2O + xenobiotic/in ABC multidrug transporter LmrA, substrate specificity Lactococcus lactis ADP + phosphate + xenobiotic/out
-
 ?
7.6.2.2 ATP + H2O + xenobiotic/in ABC multidrug transporter LmrA, substrate specificity Lactococcus lactis NZ9000 ADP + phosphate + xenobiotic/out
-
 ?
7.6.2.2 additional information possible role for LmrA in lipid trafficking Lactococcus lactis ?
-
 ?
7.6.2.2 additional information LmrA and the lipid transporter MsbA in Escherichia coli have overlapping specificities for Lipid A and chemotherapeutic and cytotoxic drugs Lactococcus lactis ?
-
 ?
7.6.2.2 additional information possible role for LmrA in lipid trafficking Lactococcus lactis NZ9000 ?
-
 ?
7.6.2.2 additional information LmrA and the lipid transporter MsbA in Escherichia coli have overlapping specificities for Lipid A and chemotherapeutic and cytotoxic drugs Lactococcus lactis NZ9000 ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
7.6.2.2 LmrA
-
 Lactococcus lactis

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
7.6.2.2 30
-
 assay at, ATPase activity Lactococcus lactis

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
7.6.2.2 7.4
-
 assay at, ATPase activity Lactococcus lactis