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Literature summary extracted from

  • Wilkinson, S.R.; Meyer, D.J.; Taylor, M.C.; Bromley, E.V.; Miles, M.A.; Kelly, J.M.
    The Trypanosoma cruzi enzyme TcGPXI is a glycosomal peroxidase and can be linked to trypanothione reduction by glutathione or tryparedoxin (2002), J. Biol. Chem., 277, 17062-17071.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.11.1.9 overexpression of TcGPXI in transfected parasites confers increased resistance to exogenous hydroperoxides Trypanosoma cruzi

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.11.1.9 cytosol
-
 Trypanosoma cruzi 5829
-
1.11.1.9 glycosome
-
 Trypanosoma cruzi 20015
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.11.1.9 additional information Trypanosoma cruzi the enzyme can reduce fatty acid, phospholipid, and short chain organic hydroperoxides utilizing a novel redox cycle in which enzyme activity is linked to the reduction of trypanothione, by glutathione. The activity of TcGPXI can also be linked to trypanothione reduction by an alternative pathway involving thioredoxin-like protein tryparedoxin. Overexpression of TcGPXI in transfected parasites confers increased resistance to exogenous hydroperoxides ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.11.1.9 Trypanosoma cruzi
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.11.1.9
-
 Trypanosoma cruzi

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.11.1.9 0.6868
-
-
 Trypanosoma cruzi

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.11.1.9 additional information the enzyme can reduce fatty acid, phospholipid, and short chain organic hydroperoxides utilizing a novel redox cycle in which enzyme activity is linked to the reduction of trypanothione, by glutathione. The activity of TcGPXI can also be linked to trypanothione reduction by an alternative pathway involving thioredoxin-like protein tryparedoxin. Overexpression of TcGPXI in transfected parasites confers increased resistance to exogenous hydroperoxides Trypanosoma cruzi ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.11.1.9 glutathione-dependent peroxidase I
-
 Trypanosoma cruzi
1.11.1.9 TcGPXI
-
 Trypanosoma cruzi