BRENDA - Enzyme Database show

A novel S-adenosyl-L-methionine:arsenic(III) methyltransferase from rat liver cytosol

Lin, S.; Shi, Q.; Nix, F.B.; Styblo, M.; Beck, M.A.; Herbin-Davis, K.M.; Hall, L.L.; Simeonsson, J.B.; Thomas, D.J.; J. Biol. Chem. 277, 10795-10803 (2002)

Data extracted from this reference:

Localization
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
2.1.1.137
cytosol
-
Rattus norvegicus
5829
-
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
2.1.1.137
Homo sapiens
Q9HBK9
-
-
2.1.1.137
Rattus norvegicus
Q8VHT6
-
-
Purification (Commentary)
EC Number
Commentary
Organism
2.1.1.137
-
Rattus norvegicus
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
2.1.1.137
adrenal gland
-
Rattus norvegicus
-
2.1.1.137
brain
-
Rattus norvegicus
-
2.1.1.137
heart
-
Rattus norvegicus
-
2.1.1.137
Hep-G2 cell
mRNA is detected after 35 or 45 cycles of amplification
Homo sapiens
-
2.1.1.137
kidney
-
Rattus norvegicus
-
2.1.1.137
liver
-
Rattus norvegicus
-
2.1.1.137
lung
-
Rattus norvegicus
-
2.1.1.137
additional information
not detected in UROtsa cells, an immortalized cell line derived from normal human urothelium, after 45 cycles of amplification
Homo sapiens
-
2.1.1.137
urinary bladder
-
Rattus norvegicus
-
Specific Activity [micromol/min/mg]
EC Number
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
2.1.1.137
0.00149
-
-
Rattus norvegicus
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.1.1.137
S-adenosyl-L-methionine + arsenite
-
659168
Rattus norvegicus
S-adenosyl-L-homocysteine + methylarsonate
-
-
-
?
2.1.1.137
S-adenosyl-L-methionine + methylarsonite
-
659168
Rattus norvegicus
S-adenosyl-L-homocysteine + dimethylarsinate
-
-
-
?
pH Optimum
EC Number
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
2.1.1.137
9.5
-
-
Rattus norvegicus
pH Range
EC Number
pH Minimum
pH Maximum
Commentary
Organism
2.1.1.137
7.5
11
pH 7.5: about 40% of maximal activity, pH 11: about 35% of maximal activity
Rattus norvegicus
Localization (protein specific)
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
2.1.1.137
cytosol
-
Rattus norvegicus
5829
-
Purification (Commentary) (protein specific)
EC Number
Commentary
Organism
2.1.1.137
-
Rattus norvegicus
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
2.1.1.137
adrenal gland
-
Rattus norvegicus
-
2.1.1.137
brain
-
Rattus norvegicus
-
2.1.1.137
heart
-
Rattus norvegicus
-
2.1.1.137
Hep-G2 cell
mRNA is detected after 35 or 45 cycles of amplification
Homo sapiens
-
2.1.1.137
kidney
-
Rattus norvegicus
-
2.1.1.137
liver
-
Rattus norvegicus
-
2.1.1.137
lung
-
Rattus norvegicus
-
2.1.1.137
additional information
not detected in UROtsa cells, an immortalized cell line derived from normal human urothelium, after 45 cycles of amplification
Homo sapiens
-
2.1.1.137
urinary bladder
-
Rattus norvegicus
-
Specific Activity [micromol/min/mg] (protein specific)
EC Number
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
2.1.1.137
0.00149
-
-
Rattus norvegicus
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.1.1.137
S-adenosyl-L-methionine + arsenite
-
659168
Rattus norvegicus
S-adenosyl-L-homocysteine + methylarsonate
-
-
-
?
2.1.1.137
S-adenosyl-L-methionine + methylarsonite
-
659168
Rattus norvegicus
S-adenosyl-L-homocysteine + dimethylarsinate
-
-
-
?
pH Optimum (protein specific)
EC Number
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
2.1.1.137
9.5
-
-
Rattus norvegicus
pH Range (protein specific)
EC Number
pH Minimum
pH Maximum
Commentary
Organism
2.1.1.137
7.5
11
pH 7.5: about 40% of maximal activity, pH 11: about 35% of maximal activity
Rattus norvegicus