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Literature summary extracted from

  • Bello, R.I.; Alcain, F.J.; Gomez-Diaz, C.; Lopez-Lluch, G.; Navas, P.; Villalba, J.M.
    Hydrogen peroxide- and cell-density-regulated expression of NADH-cytochrome b5 reductase in HeLa cells (2003), J. Bioenerg. Biomembr., 35, 169-179.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.6.2.2 additional information high levels of H2O2 inhibit enzyme expression Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.6.2.2 endoplasmic reticulum membrane
-
Homo sapiens 5789
-
1.6.2.2 mitochondrial outer membrane
-
Homo sapiens 5741
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.6.2.2 2 ferricytochrome b5 + NADH Homo sapiens involved in the synthesis of fatty acids and cholesterol, and in the oxidation of xenobiotics, participates in the regeneration of vitamin E and of ascorbate, maintains antioxidant levels and is therefore involved in the protection of membrane lipids from peroxidation, considered as a constitutive housekeeping enzyme 2 ferrocytochrome b5 + NAD+ + H+
-
?

Organism

EC Number Organism UniProt Comment Textmining
1.6.2.2 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.6.2.2 HeLa cell highest activity in confluently grown cells Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.6.2.2 2 ferricytochrome b5 + NADH
-
Homo sapiens 2 ferrocytochrome b5 + NAD+ + H+
-
?
1.6.2.2 2 ferricytochrome b5 + NADH involved in the synthesis of fatty acids and cholesterol, and in the oxidation of xenobiotics, participates in the regeneration of vitamin E and of ascorbate, maintains antioxidant levels and is therefore involved in the protection of membrane lipids from peroxidation, considered as a constitutive housekeeping enzyme Homo sapiens 2 ferrocytochrome b5 + NAD+ + H+
-
?

Cofactor

EC Number Cofactor Comment Organism Structure
1.6.2.2 FAD
-
Homo sapiens
1.6.2.2 NADH
-
Homo sapiens