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Literature summary extracted from
- Steady-state kinetics of NADH:coenzyme Q oxidoreductase isolated from bovine heart mitochondria (2002), J. Bioenerg. Biomembr., 34, 11-19.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 7.1.1.2 | NAD+ | product inhibition | Bos taurus |  |
| 7.1.1.2 | reduced coenzyme Q1 | product inhibition | Bos taurus | |
| 7.1.1.2 | rotenone | 150 nM, 85% inhibition in presence of 0.01 mM NADH, inhibition is independent of coenzyme Q1 concentration below 0.05 mM, rotenone sensitivity decreases significantly with coenzyme Q1 concentration above 0.1 mM | Bos taurus | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 7.1.1.2 | 0.00172 | - |
NADH | with 0.01 mM coenzyme Q1 | Bos taurus | |
| 7.1.1.2 | 0.00195 | - |
NADH | with 0.025 mM coenzyme Q1 | Bos taurus | |
| 7.1.1.2 | 0.002 | - |
NADH | with 0.05 mM coenzyme Q1 | Bos taurus | |
| 7.1.1.2 | 0.0129 | - |
coenzyme Q1 | - |
Bos taurus | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 7.1.1.2 | mitochondrion | - |
Bos taurus | 5739 | - |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 7.1.1.2 | Bos taurus | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 7.1.1.2 | heart | - |
Bos taurus | - |
Storage Stability
| EC Number | Storage Stability | Organism |
|---|---|---|
| 7.1.1.2 | -80°C, 8-10 mg protein/ml, stable for at least 1 year | Bos taurus |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 7.1.1.2 | NADH + H+ + coenzyme Q1 | ordered sequential mechanism in which the order of substrate binding and product release is coenzyme Q1, NADH, NAD+ and reduced coenzyme coenzyme Q1 | Bos taurus | NAD+ + reduced coenzyme Q1 | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 7.1.1.2 | NADH:coenzyme Q oxidoreductase | - |
Bos taurus |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 7.1.1.2 | NADH | - |
Bos taurus | |
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Release 2023.1 (January 2023)
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