EC Number | Application | Comment | Organism |
---|---|---|---|
1.8.1.15 | medicine | the enzyme is sensitive to free radical generating antituberculosis drugs and may be useful target for new drug development | Mycobacterium tuberculosis variant bovis |
3.5.1.103 | medicine | antisense oligonucleotides to GlcNAc-Ins deacetylase (Rv1170) mRNA affect mycobacterial growth. The enzyme is sensitive to free radical generating antituberculosis drugs and may be a useful targets for new drug development | Mycobacterium tuberculosis |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.8.1.15 | mycothione + NADPH | Mycobacterium tuberculosis variant bovis | the enzyme is involved in mycothiol metabolism. Mycothiol may play an important role in the survival and adaption of mycobacteria to oxidative stress caused by normal metabolism, ir induced by the action of anti-tubercular drugs | mycothiol + NADP+ | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.8.1.15 | Mycobacterium tuberculosis variant bovis | - |
- |
- |
3.5.1.103 | Mycobacterium tuberculosis | P9WJN3 | - |
- |
3.5.1.103 | Mycobacterium tuberculosis H37Rv | P9WJN3 | - |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.8.1.15 | cell culture | gene is actively transcribed during logarithmic growth | Mycobacterium tuberculosis variant bovis | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.8.1.15 | mycothione + NADPH | the enzyme is involved in mycothiol metabolism. Mycothiol may play an important role in the survival and adaption of mycobacteria to oxidative stress caused by normal metabolism, ir induced by the action of anti-tubercular drugs | Mycobacterium tuberculosis variant bovis | mycothiol + NADP+ | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.8.1.15 | NADPH-dependent mycothiol reductase | - |
Mycobacterium tuberculosis variant bovis |
3.5.1.103 | GlcNAc-Ins deacetylase | - |
Mycobacterium tuberculosis |
3.5.1.103 | Rv1170 | - |
Mycobacterium tuberculosis |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.8.1.15 | NADPH | - |
Mycobacterium tuberculosis variant bovis |