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Literature summary extracted from

  • Chen, J.S.; Berenbaum, M.R.; Schuler, M.A.
    Amino acids in SRS1 and SRS6 are critical for furanocoumarin metabolism by CYP6B1v1, a cytochrome P450 monooxygenase (2002), Insect Mol. Biol., 11, 175-186.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
1.14.14.1 F116A no enzymatic activity Papilio polyxenes
1.14.14.1 F116C no enzymatic activity Papilio polyxenes
1.14.14.1 F116H no enzymatic activity Papilio polyxenes
1.14.14.1 F116I no enzymatic activity Papilio polyxenes
1.14.14.1 F116L no enzymatic activity Papilio polyxenes
1.14.14.1 F116L/F484L no enzymatic activity Papilio polyxenes
1.14.14.1 F116L/F484Y no enzymatic activity Papilio polyxenes
1.14.14.1 F116S no enzymatic activity Papilio polyxenes
1.14.14.1 F116V no enzymatic activity Papilio polyxenes
1.14.14.1 F116W some enzymatic activity against bergapten, xanthotoxin Papilio polyxenes
1.14.14.1 F116Y reduced enzymatic activity Papilio polyxenes
1.14.14.1 F116Y/F484H no enzymatic activity Papilio polyxenes
1.14.14.1 F116Y/F484Y no enzymatic activity Papilio polyxenes
1.14.14.1 F206L no enzymatic activity Papilio polyxenes
1.14.14.1 F484C no enzymatic activity Papilio polyxenes
1.14.14.1 F484D no enzymatic activity Papilio polyxenes
1.14.14.1 F484H no enzymatic activity Papilio polyxenes
1.14.14.1 F484L no enzymatic activity Papilio polyxenes
1.14.14.1 F484S no enzymatic activity Papilio polyxenes
1.14.14.1 F484V no enzymatic activity Papilio polyxenes
1.14.14.1 F484W no enzymatic activity Papilio polyxenes
1.14.14.1 F484Y no enzymatic activity Papilio polyxenes
1.14.14.1 H117A no enzymatic activity Papilio polyxenes
1.14.14.1 H117F no enzymatic activity Papilio polyxenes
1.14.14.1 H117L/F484Y no enzymatic activity Papilio polyxenes
1.14.14.1 H117V no enzymatic activity Papilio polyxenes
1.14.14.1 H117Y no enzymatic activity Papilio polyxenes
1.14.14.1 H204L activity similar to wild-type Papilio polyxenes
1.14.14.1 V368A no enzymatic activity Papilio polyxenes
1.14.14.1 V368A activity similar to wild-type Papilio polyxenes
1.14.14.1 V368F no enzymatic activity Papilio polyxenes
1.14.14.1 V368L no enzymatic activity Papilio polyxenes
1.14.14.1 V368L activity similar to wild-type Papilio polyxenes

Organism

EC Number Organism UniProt Comment Textmining
1.14.14.1 Papilio polyxenes Q04552 black swallowtail caterpillar
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.14.1 2-hydroxy-1-(4-hydroxyphenyl)guanidine + [reduced NADPH-hemoprotein reductase] + O2
-
 Papilio polyxenes ?
-
 ?
1.14.14.1 bergapten + [reduced NADPH-hemoprotein reductase] + O2
-
 Papilio polyxenes ? + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.1 isopimpinellin + [reduced NADPH-hemoprotein reductase] + O2
-
 Papilio polyxenes ? + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.1 psoralen + [reduced NADPH-hemoprotein reductase] + O2
-
 Papilio polyxenes ? + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.1 xanthotoxin + reduced flavoprotein + O2
-
 Papilio polyxenes ? + oxidized flavoprotein + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.14.1 CYP6B1v1
-
 Papilio polyxenes

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.14.1 cytochrome P450
-
 Papilio polyxenes