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Literature summary extracted from

  • Shirai, H.; Mizuguchi, K.
    Prediction of the structure and function of AstA and AstB, the first two enzymes of the arginine succinyltransferase pathway of arginine catabolism (2003), FEBS Lett., 555, 505-510.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.109 succinyl-CoA + L-arginine Escherichia coli first step in arginine succinyltransferase pathway of arginine catabolism, pathway evolution, overview CoA + N2-succinyl-L-arginine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.109 Escherichia coli
-
-
-
3.5.3.23 Escherichia coli P76216
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
2.3.1.109 succinyl-CoA + L-arginine = CoA + N2-succinyl-L-arginine catalytic mechanism involving Glu121, His229, and Leu125, catalytic domain structure Escherichia coli
a
3.5.3.23 N2-succinyl-L-arginine + 2 H2O = N2-succinyl-L-ornithine + 2 NH3 + CO2 mechanism consists of two cycles of hydrolysis and ammonia release, with each cycle utilizing a mechanism similar to that proposed for arginine deiminases Escherichia coli
a

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.109 succinyl-CoA + L-arginine
-
 Escherichia coli CoA + N2-succinyl-L-arginine
-
 ?
2.3.1.109 succinyl-CoA + L-arginine first step in arginine succinyltransferase pathway of arginine catabolism, pathway evolution, overview Escherichia coli CoA + N2-succinyl-L-arginine
-
 ?

Subunits

EC Number Subunits Comment Organism
2.3.1.109 More three-dimensional structure analysis Escherichia coli
3.5.3.23 More sequence-structure homology study Escherichia coli

Synonyms

EC Number Synonyms Comment Organism
2.3.1.109 arginine succinyltransferase
-
 Escherichia coli
2.3.1.109 AST
-
 Escherichia coli
2.3.1.109 AstA
-
 Escherichia coli
2.3.1.109 More enzyme belongs to the acyl-CoA N-acyltransferase superfamily Escherichia coli

Cofactor

EC Number Cofactor Comment Organism Structure
2.3.1.109 succinyl-CoA
-
 Escherichia coli