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Literature summary extracted from

  • Tachibana, A.
    A novel prenyltransferase, farnesylgeranyl diphosphate synthase, from the haloalkaliphilic archaeon, Natronobacterium pharaonis (1994), FEBS Lett., 341, 291-294.
    View publication on PubMed

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.5.1.81 76000
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 gel filtration Natronomonas pharaonis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.5.1.81 geranylgeranyl diphosphate + isopentenyl diphosphate Natronomonas pharaonis the enzyme may synthesize a precursor for the C25 moiety of C20,C25 diether lipids (2E,6E,10E,14E)-geranylfarnesyl diphosphate + diphosphate
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 ?

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.81 Natronomonas pharaonis
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-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.5.1.81
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 Natronomonas pharaonis

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.81 (2E,6E)-farnesyl diphosphate + 2 isopentenyl diphosphate farnesyl diphosphate shows 93% of the activity with geranylgeranyl diphosphate. Stereochemistry of farnesylgeranyl diphosphate synthesized by FGPP synthase is unclear, but may be an all-E isomer because the same isomer is produced when dimethylallyl diphosphate, geranyl diphosphate, and (all-E)-farnesyl diphosphate, as well as (all-E)-geranylgeranyl diphosphate, are used as substrates. The stereochemistry of the C25 moiety of C20,C25-diether lipids is identical with that of the C20 moiety Natronomonas pharaonis (2E,6E,10E,14E)-geranylfarnesyl diphosphate + 2 diphosphate
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 ?
2.5.1.81 dimethylallyl diphosphate + 4 isopentenyl diphosphate dimethylallyl diphosphate shows 51% of the activity with farnesyl diphosphate. Stereochemistry of farnesylgeranyl diphosphate synthesized by FGPP synthase is unclear, but may be an all-E isomer because the same isomer is produced when dimethylallyl diphosphate, geranyl diphosphate, and (all-E)-farnesyl diphosphate, as well as (all-E)-geranylgeranyl diphosphate, are used as substrates. The stereochemistry of the C25 moiety of C20,C25-diether lipids is identical with that of the C20 moiety Natronomonas pharaonis (2E,6E,10E,14E)-geranylfarnesyl diphosphate + 4 diphosphate large amounts of intermediates are formed: geranyl diphosphate, farnesyl diphosphate, geranylgeranyl diphosphate ?
2.5.1.81 geranyl diphosphate + 3 isopentenyl diphosphate geranyl diphosphate shows 81% of the activity with farnesyl diphosphate. Stereochemistry of farnesylgeranyl diphosphate synthesized by FGPP synthase is unclear, but may be an all-E isomer because the same isomer is produced when dimethylallyl diphosphate, geranyl diphosphate, and (all-E)-farnesyl diphosphate, as well as (all-E)-geranylgeranyl diphosphate, are used as substrates. The stereochemistry of the C25 moiety of C20,C25-diether lipids is identical with that of the C20 moiety Natronomonas pharaonis (2E,6E,10E,14E)-geranylfarnesyl diphosphate + 3 diphosphate
-
 ?
2.5.1.81 geranylgeranyl diphosphate + isopentenyl diphosphate the enzyme may synthesize a precursor for the C25 moiety of C20,C25 diether lipids Natronomonas pharaonis (2E,6E,10E,14E)-geranylfarnesyl diphosphate + diphosphate
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 ?
2.5.1.81 geranylgeranyl diphosphate + isopentenyl diphosphate geranylgeranyl diphosphate is the allylic substrate with the highest activity. Stereochemistry of farnesylgeranyl diphosphate synthesized by FGPP synthase is unclear, but may be an all-E isomer because the same isomer is produced when dimethylallyl diphosphate, geranyl diphosphate, and (all-E)-farnesyl diphosphate, as well as (all-E)-geranylgeranyl diphosphate, are used as substrates. The stereochemistry of the C25 moiety of C20,C25-diether lipids is identical with that of the C20 moiety Natronomonas pharaonis (2E,6E,10E,14E)-geranylfarnesyl diphosphate + diphosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.5.1.81 farnesyl diphosphate synthase
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-
2.5.1.81 FGPP synthase
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 Natronomonas pharaonis