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Literature summary extracted from

  • Han, Q.; Li, J.
    pH dependence, substrate specificity and inhibition of human kynurenine aminotransferase I (2004), Eur. J. Biochem., 271, 4804-4814.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.6.1.7 cysteine
-
Homo sapiens
2.6.1.7 Indole-3-pyruvate 5 mM, complete inhibition Homo sapiens
2.6.1.7 Tris Tris buffer pH 7.5, low activity, pH 8.0, no activity Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.6.1.7 0.7
-
L-cysteine pH 7.5, 45°C Homo sapiens
2.6.1.7 0.8
-
phenylpyruvate pH 7.5, 45°C Homo sapiens
2.6.1.7 1
-
2-oxoisocaproate pH 7.5, 45°C Homo sapiens
2.6.1.7 1.2
-
L-tryptophan pH 7.5, 45°C Homo sapiens
2.6.1.7 1.5
-
glyoxylate pH 7.5, 45°C Homo sapiens
2.6.1.7 1.7
-
L-phenylalanine pH 7.5, 45°C Homo sapiens
2.6.1.7 2.5
-
Mercaptopyruvate pH 7.5, 45°C Homo sapiens
2.6.1.7 2.8
-
L-glutamine pH 7.5, 45°C Homo sapiens
2.6.1.7 3
-
2-oxobutanoate pH 7.5, 45°C Homo sapiens
2.6.1.7 3.2
-
L-tyrosine pH 7.5, 45°C Homo sapiens
2.6.1.7 4.2
-
oxaloacetate pH 7.5, 45°C Homo sapiens
2.6.1.7 4.7
-
L-kynurenine pH 7.5, 45°C Homo sapiens
2.6.1.7 5.4
-
L-histidine pH 7.5, 45°C Homo sapiens
2.6.1.7 6.4
-
L-methionine pH 7.5, 45°C Homo sapiens
2.6.1.7 7.6
-
L-leucine pH 7.5, 45°C Homo sapiens
2.6.1.7 12.1
-
pyruvate pH 7.5, 45°C Homo sapiens
2.6.1.7 21.3
-
2-aminobutanoate pH 7.5, 45°C Homo sapiens
2.6.1.7 23.1
-
L-asparagine pH 7.5, 45°C Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.6.1.7 46000
-
x * 46000, SDS-PAGE, x * 47875, calculated Homo sapiens
2.6.1.7 47875
-
x * 46000, SDS-PAGE, x * 47875, calculated Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.6.1.7 Homo sapiens
-
expression in Sf9 system
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.6.1.7 brain
-
Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.6.1.7 L-asparagine + 2-oxobutanoate
-
Homo sapiens 2-oxosuccinamic acid + 2-aminobutanoate
-
?
2.6.1.7 L-cysteine + 2-oxobutanoate
-
Homo sapiens 2-aminobutanoate + 3-mercapto-2-oxopropanoate
-
?
2.6.1.7 L-glutamine + 2-oxobutanoate
-
Homo sapiens 2-oxoglutarate + 2-aminobutanoate
-
?
2.6.1.7 L-histidine + 2-oxobutanoate
-
Homo sapiens 3-(1H-imidazol-4-yl)-2-oxopropanoate + 2-aminobutanoate
-
?
2.6.1.7 L-kynurenine + 2-oxobutanoate
-
Homo sapiens 4-(2-aminophenyl)-2,4-dioxobutanoate + 2-aminobutanoate
-
?
2.6.1.7 L-kynurenine + 2-oxoisocaproate
-
Homo sapiens 4-(2-aminophenyl)-2,4-dioxobutanoate + L-leucine
-
?
2.6.1.7 L-kynurenine + glyoxylate
-
Homo sapiens 4-(2-aminophenyl)-2,4-dioxobutanoate + glycine
-
?
2.6.1.7 L-kynurenine + mercaptopyruvate
-
Homo sapiens 4-(2-aminophenyl)-2,4-dioxobutanoate + L-cysteine
-
?
2.6.1.7 L-kynurenine + oxaloacetate
-
Homo sapiens 4-(2-aminophenyl)-2,4-dioxobutanoate + 2-aminosuccinate
-
?
2.6.1.7 L-kynurenine + phenylpyruvate
-
Homo sapiens 4-(2-aminophenyl)-2,4-dioxobutanoate + L-phenylalanine
-
?
2.6.1.7 L-kynurenine + pyruvate
-
Homo sapiens 4-(2-aminophenyl)2,4-dioxobutanoate + L-alanine
-
?
2.6.1.7 L-leucine + 2-oxobutanoate
-
Homo sapiens 2-oxoisocaproate + 2-aminobutanoate
-
?
2.6.1.7 L-methionine + 2-oxobutanoate
-
Homo sapiens 4-methylsulfanyl-2-oxobutanoate + 2-aminobutanoate
-
?
2.6.1.7 L-phenylalanine + 2-oxobutanoate
-
Homo sapiens phenylpyruvate + 2-aminobutanoate
-
?
2.6.1.7 L-tryptophan + 2-oxobutanoate
-
Homo sapiens 3-indole-2-oxopropanoate + 2-aminobutanoate
-
?
2.6.1.7 L-tyrosine + 2-oxobutanoate
-
Homo sapiens 3-(4-hydroxyphenyl)-2-oxopropanoate + 2-aminobutanoate
-
?
2.6.1.7 additional information very bad substrate: L-glycine, L-alanine, L-arginine, L-serine, L-lysine, no substrate: l-threonine, L-isoleucine, L-aspartate, L-glutamate, L-valine, L-aminoadipate Homo sapiens ?
-
?

Subunits

EC Number Subunits Comment Organism
2.6.1.7 ? x * 46000, SDS-PAGE, x * 47875, calculated Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
2.6.1.7 KAT-I
-
Homo sapiens

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
2.6.1.7 9.6
-
L-cysteine pH 7.5, 45°C Homo sapiens
2.6.1.7 14.4
-
L-asparagine pH 7.5, 45°C Homo sapiens
2.6.1.7 29
-
pyruvate pH 7.5, 45°C Homo sapiens
2.6.1.7 38.3
-
2-aminobutanoate pH 7.5, 45°C Homo sapiens
2.6.1.7 43.1
-
L-tryptophan pH 7.5, 45°C Homo sapiens
2.6.1.7 91
-
L-phenylalanine pH 7.5, 45°C Homo sapiens
2.6.1.7 91
-
L-tyrosine pH 7.5, 45°C Homo sapiens
2.6.1.7 110
-
phenylpyruvate pH 7.5, 45°C Homo sapiens
2.6.1.7 143
-
oxaloacetate pH 7.5, 45°C Homo sapiens
2.6.1.7 143
-
L-histidine pH 7.5, 45°C Homo sapiens
2.6.1.7 201
-
L-kynurenine pH 7.5, 45°C Homo sapiens
2.6.1.7 215
-
L-methionine pH 7.5, 45°C Homo sapiens
2.6.1.7 234
-
2-oxobutanoate pH 7.5, 45°C Homo sapiens
2.6.1.7 234
-
Mercaptopyruvate pH 7.5, 45°C Homo sapiens
2.6.1.7 263
-
glyoxylate pH 7.5, 45°C Homo sapiens
2.6.1.7 296
-
2-oxoisocaproate pH 7.5, 45°C Homo sapiens
2.6.1.7 339
-
L-leucine pH 7.5, 45°C Homo sapiens
2.6.1.7 440
-
L-glutamine pH 7.5, 45°C Homo sapiens

pH Range

EC Number pH Minimum pH Maximum Comment Organism
2.6.1.7 7.5 9
-
Homo sapiens