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Literature summary extracted from

  • Tachibana, A.; Yano, Y.; Otani, S.; Nomura, N.; Sako, Y.; Taniguchi, M.
    Novel prenyltransferase gene encoding farnesylgeranyl diphosphate synthase from a hyperthermophilic archaeon,Aeropyrum pernix. Molecular evolution with alteration in product specificity (2000), Eur. J. Biochem., 267, 321-328.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.5.1.81 expressed in Escherichia coli as a glutathione S-transferase fusion protein Aeropyrum pernix

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.5.1.81 (2E,6E)-farnesyl diphosphate + 2 isopentenyl diphosphate Aeropyrum pernix Aeropyrum pernix does not possess geranylgeranyl diphosphate synthase and has only C25-C25 ether lipids, but no C20-containing ether lipids. Aeropyrum pernix farnesylgeranyl diphosphate synthase is important in the biosynthesis of the hydrocarbon moiety of membrane lipids (2E,6E,10E,14E)-geranylfarnesyl diphosphate + 2 diphosphate
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?

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.81 Aeropyrum pernix Q9UWR6
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-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.5.1.81
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Aeropyrum pernix

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.81 (2E,6E)-farnesyl diphosphate + 2 isopentenyl diphosphate Aeropyrum pernix does not possess geranylgeranyl diphosphate synthase and has only C25-C25 ether lipids, but no C20-containing ether lipids. Aeropyrum pernix farnesylgeranyl diphosphate synthase is important in the biosynthesis of the hydrocarbon moiety of membrane lipids Aeropyrum pernix (2E,6E,10E,14E)-geranylfarnesyl diphosphate + 2 diphosphate
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?
2.5.1.81 (2E,6E)-farnesyl diphosphate + 2 isopentenyl diphosphate farnesyl diphosphate is the allylic substrate with the highest activity Aeropyrum pernix (2E,6E,10E,14E)-geranylfarnesyl diphosphate + 2 diphosphate
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?
2.5.1.81 dimethylallyl diphosphate + 4 isopentenyl diphosphate dimethylallyl diphosphate shows 28% of the activity with farnesyl diphosphate Aeropyrum pernix (2E,6E,10E,14E)-geranylfarnesyl diphosphate + 4 diphosphate large amounts of intermediates are formed: geranyl diphosphate, farnesyl diphosphate, geranylgeranyl diphosphate ?
2.5.1.81 geranyl diphosphate + 3 isopentenyl diphosphate geranyl diphosphate shows 72% of the activity with farnesyl diphosphate Aeropyrum pernix (2E,6E,10E,14E)-geranylfarnesyl diphosphate + 3 diphosphate
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?
2.5.1.81 geranylgeranyl diphosphate + isopentenyl diphosphate geranylgeranyl diphosphate shows 65% of the activity with farnesyl diphosphate Aeropyrum pernix (2E,6E,10E,14E)-geranylfarnesyl diphosphate + diphosphate
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?

Synonyms

EC Number Synonyms Comment Organism
2.5.1.81 C25 farnesylgeranyl diphosphate synthase
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2.5.1.81 farnesylgeranyl diphosphate synthase
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2.5.1.81 FGPP synthase
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Aeropyrum pernix
2.5.1.81 Fgs
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Aeropyrum pernix

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.5.1.81 7.5
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assay at Aeropyrum pernix