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Literature summary extracted from

  • Toll, A.; Wikvall, K.; Sudjana-Sugiaman, E.; Kondo, K.H.; Bj๖rhem, I.
    7alpha-Hydroxylation of 25-hydroxycholesterol in liver microsomes. Evidence that the enzyme involved is different from cholesterol 7alpha-hydoxylase (1994), Eur. J. Biochem., 224, 309-316.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.14.29 microsome
-
 Homo sapiens
-
-
1.14.14.29 microsome
-
 Rattus norvegicus
-
-
1.14.14.29 microsome
-
 Sus scrofa
-
-

Organism

EC Number Organism UniProt Comment Textmining
1.14.14.29 Homo sapiens
-
-
-
1.14.14.29 Rattus norvegicus
-
-
-
1.14.14.29 Sus scrofa
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.14.29 liver
-
 Homo sapiens
-
1.14.14.29 liver
-
 Rattus norvegicus
-
1.14.14.29 liver
-
 Sus scrofa
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.14.29 cholest-5-ene-3beta,25-diol + NADPH + H+ + O2
-
 Homo sapiens cholest-5-ene-3beta,7alpha,25-triol + NADP+ + H2O
-
 ?
1.14.14.29 cholest-5-ene-3beta,25-diol + NADPH + H+ + O2
-
 Rattus norvegicus cholest-5-ene-3beta,7alpha,25-triol + NADP+ + H2O
-
 ?
1.14.14.29 cholest-5-ene-3beta,25-diol + NADPH + H+ + O2
-
 Sus scrofa cholest-5-ene-3beta,7alpha,25-triol + NADP+ + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.14.29 25-hydroxycholesterol 7alpha-monooxygenase
-
 Sus scrofa
1.14.14.29 CYP7B1
-
 Sus scrofa
1.14.14.29 CYP7B1 oxysterol 7alpha-hydroxylase
-
 Sus scrofa

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.14.29 NADPH
-
 Homo sapiens
1.14.14.29 NADPH
-
 Rattus norvegicus
1.14.14.29 NADPH
-
 Sus scrofa