Literature summary extracted from

Kishimoto, W.; Hiroi, T.; Shiraishi, M.; Osada, M.; Imaoka, S.; Kominami, S.; Igarashi, T.; Funae, Y.
Cytochrome P450 2D catalyze steroid 21-hydroxylation in the brain (2004), Endocrinology, 145, 699-705.

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
1.14.14.16	fluoxetine	50% inhibition at 0.002 mM, substrate allopregnanolone	Rattus norvegicus
1.14.14.16	quinidine	-	Rattus norvegicus

Localization

EC Number	Localization	Comment	Organism	GeneOntology No.	Textmining
1.14.14.16	microsome	microsomal steroid 21-hydroxylation is not catalyzed by P450c21, but by CYP2D isoforms	Rattus norvegicus	-	-

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.14.14.16	Rattus norvegicus	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
1.14.14.16	brain	-	Rattus norvegicus	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1.14.14.16	17-hydroxy-progesterone + NADH + O2	isozyme CYP2D	Rattus norvegicus	17-hydroxy-11-deoxy-corticosterone + NAD+ + H2O	-	?
1.14.14.16	allopregnanolone + NADH + O2	isozyme CYP2D4, CYP2D6	Rattus norvegicus	21-hydroxy-allopregnanolone + NAD+ + H2O	-	?
1.14.14.16	progesterone + NADH + O2	isozyme CYP2D	Rattus norvegicus	deoxycorticosterone + NAD+ + H2O	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
1.14.14.16	CYP2D	-	Rattus norvegicus

Cofactor

EC Number	Cofactor	Comment	Organism	Structure
1.14.14.16	NADH	-	Rattus norvegicus

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Release 2023.1 (January 2023)