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Literature summary extracted from

  • Lemberg, M.K.; Menendez, J.; Misik, A.; Garcia, M.; Koth, C.M.; Freeman, M.
    Mechanism of intramembrane proteolysis investigated with purified rhomboid proteases (2005), EMBO J., 24, 464-472.
    View publication on PubMedView publication on EuropePMC

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.105 Aquifex aeolicus
-
 recombinant enzyme expressed in Escherichia coli
-
3.4.21.105 Bacillus subtilis
-
-
-
3.4.21.105 Drosophila sp. (in: flies)
-
 recombinant enzyme expressed in Escherichia coli
-
3.4.21.105 Escherichia coli
-
-
-
3.4.21.105 Homo sapiens Q9NX52 recombinant enzyme expressed in Escherichia coli
-
3.4.21.105 Providencia stuartii
-
 recombinant enzyme expressed in Escherichia coli
-
3.4.21.105 Pseudomonas aeruginosa
-
 recombinant enzyme expressed in Escherichia coli
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.21.105
-
 Bacillus subtilis
3.4.21.105
-
 Escherichia coli

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.105 Delta-transmembrane domain + H2O slight activity Pseudomonas aeruginosa ?
-
 ?
3.4.21.105 Delta-transmembrane domain + H2O slight activity Aquifex aeolicus ?
-
 ?
3.4.21.105 Gurken-transmembrane domain + H2O
-
 Drosophila sp. (in: flies) ?
-
 ?
3.4.21.105 Gurken-transmembrane domain + H2O
-
 Pseudomonas aeruginosa ?
-
 ?
3.4.21.105 Gurken-transmembrane domain + H2O
-
 Providencia stuartii ?
-
 ?
3.4.21.105 Gurken-transmembrane domain + H2O
-
 Aquifex aeolicus ?
-
 ?
3.4.21.105 Gurken-transmembrane domain + H2O
-
 Homo sapiens ?
-
 ?
3.4.21.105 additional information no cleavage of Gurken-transmembrane domain Bacillus subtilis ?
-
 ?
3.4.21.105 additional information no cleavage of Gurken-transmembrane domain Escherichia coli ?
-
 ?
3.4.21.105 Spitz-transmembrane domain + H2O
-
 Pseudomonas aeruginosa ?
-
 ?
3.4.21.105 Spitz-transmembrane domain + H2O
-
 Providencia stuartii ?
-
 ?
3.4.21.105 Spitz-transmembrane domain + H2O
-
 Aquifex aeolicus ?
-
 ?
3.4.21.105 Spitz-transmembrane domain + H2O little activity Drosophila sp. (in: flies) ?
-
 ?
3.4.21.105 Spitz-transmembrane domain + H2O little activity Homo sapiens ?
-
 ?

Subunits

EC Number Subunits Comment Organism
3.4.21.105 More rhomboids do not function as a part of a multiprotein complex Escherichia coli
3.4.21.105 More rhomboids do not function as a partof a multiprotein complex Bacillus subtilis

Synonyms

EC Number Synonyms Comment Organism
3.4.21.105 AarA
-
 Providencia stuartii
3.4.21.105 GlpG
-
 Escherichia coli
3.4.21.105 RHBDL2
-
 Homo sapiens
3.4.21.105 rhomboid-1
-
 Drosophila sp. (in: flies)
3.4.21.105 Yqgp
-
 Bacillus subtilis