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Literature summary extracted from

  • Urban, S.; Lee Jeffrey, R.; Freeman, M.
    A family of Rhomboid intramembrane proteases activates all Drosophila membrane-tethered EGF ligands (2002), EMBO J., 21, 4277-4286.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.105 Gurken + H2O Drosophila sp. (in: flies)
-
 ?
-
 ?
3.4.21.105 Keren + H2O Drosophila sp. (in: flies)
-
 ?
-
 ?
3.4.21.105 protein Gurken + H2O Drosophila sp. (in: flies)
-
 ?
-
 ?
3.4.21.105 protein Keren + H2O Drosophila sp. (in: flies)
-
 ?
-
 ?
3.4.21.105 protein Spitz + H2O Drosophila sp. (in: flies) rhomboids 1-4 are all dedicated to regulating EGF receptor signalling ?
-
 ?
3.4.21.105 protein Spitz + H2O Drosophila sp. (in: flies) when Spitz is cleaved by rhomboids in the endoplasmic reticulum it cannot be secreted. Star regulates Spitz cleavage by rhomboid-1 by transporting Spitz to the Golgi apparatus. Rhomboids 1-4 are all dedicated to regulating EGF receptor signalling ?
-
 ?
3.4.21.105 Spitz + H2O Drosophila sp. (in: flies) rhomboids 1-4 are all dedicated to regulating EGF receptor signalling ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.105 Drosophila sp. (in: flies)
-
-
-
3.4.21.105 Drosophila sp. (in: flies)
-
 rhomboid-1
-
3.4.21.105 Drosophila sp. (in: flies)
-
 rhomboid-2
-
3.4.21.105 Drosophila sp. (in: flies)
-
 rhomboid-3
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.105 Gurken + H2O
-
 Drosophila sp. (in: flies) ?
-
 ?
3.4.21.105 Gurken + H2O cleavage by rhomboid 4 Drosophila sp. (in: flies) ?
-
 ?
3.4.21.105 Keren + H2O
-
 Drosophila sp. (in: flies) ?
-
 ?
3.4.21.105 Keren + H2O cleavage by rhomboid 4 Drosophila sp. (in: flies) ?
-
 ?
3.4.21.105 protein Gurken + H2O
-
 Drosophila sp. (in: flies) ?
-
 ?
3.4.21.105 protein Gurken + H2O cleavage by rhomboid 1 Drosophila sp. (in: flies) ?
-
 ?
3.4.21.105 protein Gurken + H2O cleavage by rhomboid 2 Drosophila sp. (in: flies) ?
-
 ?
3.4.21.105 protein Gurken + H2O cleavage by rhomboid 3 Drosophila sp. (in: flies) ?
-
 ?
3.4.21.105 protein Keren + H2O
-
 Drosophila sp. (in: flies) ?
-
 ?
3.4.21.105 protein Keren + H2O cleavage by rhomboid 1 Drosophila sp. (in: flies) ?
-
 ?
3.4.21.105 protein Keren + H2O cleavage by rhomboid 2 Drosophila sp. (in: flies) ?
-
 ?
3.4.21.105 protein Keren + H2O cleavage by rhomboid 3 Drosophila sp. (in: flies) ?
-
 ?
3.4.21.105 protein Spitz + H2O rhomboids 1-4 are all dedicated to regulating EGF receptor signalling Drosophila sp. (in: flies) ?
-
 ?
3.4.21.105 protein Spitz + H2O when Spitz is cleaved by rhomboids in the endoplasmic reticulum it cannot be secreted. Star regulates Spitz cleavage by rhomboid-1 by transporting Spitz to the Golgi apparatus. Rhomboids 1-4 are all dedicated to regulating EGF receptor signalling Drosophila sp. (in: flies) ?
-
 ?
3.4.21.105 protein Spitz + H2O cleavage by rhomboid 1 Drosophila sp. (in: flies) ?
-
 ?
3.4.21.105 protein Spitz + H2O cleavage by rhomboid 2 Drosophila sp. (in: flies) ?
-
 ?
3.4.21.105 protein Spitz + H2O cleavage by rhomboid 3 Drosophila sp. (in: flies) ?
-
 ?
3.4.21.105 Spitz + H2O rhomboids 1-4 are all dedicated to regulating EGF receptor signalling Drosophila sp. (in: flies) ?
-
 ?
3.4.21.105 Spitz + H2O cleavage by rhomboid 4 Drosophila sp. (in: flies) ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.105 rhomboid-1
-
 Drosophila sp. (in: flies)
3.4.21.105 rhomboid-2
-
 Drosophila sp. (in: flies)
3.4.21.105 rhomboid-3
-
 Drosophila sp. (in: flies)
3.4.21.105 rhomboid-4
-
 Drosophila sp. (in: flies)