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Literature summary extracted from

  • Zaks, A.; Dodds, D.R.
    Application of biocatalysts and biotransformation to the synthesis of pharmaceuticals (1997), Drug Discov. Today, 2, 513-531.
No PubMed abstract available

Application

EC Number Application Comment Organism
2.4.2.2 synthesis production of ribavirin, which is an antiviral drug Pectobacterium carotovorum
3.5.1.11 synthesis production of (2R,3S)-beta-lactam intermediate Priestia megaterium

Organism

EC Number Organism UniProt Comment Textmining
2.4.2.2 Pectobacterium carotovorum
-
-
-
3.2.2.1 Pectobacterium carotovorum
-
-
-
3.5.1.11 Priestia megaterium
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.2 1,2,4-triazole-3-carboxamide + alpha-D-ribose 1-phosphate
-
 Pectobacterium carotovorum ribavirin + phosphate
-
 ?
3.2.2.1 adenosine + H2O
-
 Pectobacterium carotovorum adenine + D-ribose
-
 ?
3.2.2.1 uridine + H2O
-
 Pectobacterium carotovorum uracil + D-ribose
-
 ?
3.5.1.11 [(2R,3S),(2S,3R)]-cis-3-amino-azetidinone + phenoxy-acetic acid methyl ester
-
 Priestia megaterium (2R,3S)-beta-lactam intermediate + methanol
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.4.2.2 60
-
-
 Pectobacterium carotovorum
3.2.2.1 60
-
-
 Pectobacterium carotovorum
3.5.1.11 28
-
-
 Priestia megaterium

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.5.1.11 6
-
-
 Priestia megaterium