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Literature summary extracted from

  • Zhan, H.C.; Gudas, L.J.; Bok, D.; Rando, R.; Nanus, D.M.; Tickoo, S.K.
    Differential expression of the enzyme that esterifies retinol, lecithin:retinol acyltransferase, in subtypes of human renal cancer and normal kidney (2003), Clin. Cancer Res., 9, 4897-4905.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.3.1.135 diagnostics enzyme might be a prognostic or therapeutic marker in renal cancer Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.135 phosphatidylcholine + retinol-[cellular-retinol-binding-protein] Homo sapiens renal cell carcinomata contain greatly reduced levels of retinol and retinyl esters relative to healthy kidney tissue 2-acylglycerophosphocholine + retinyl-ester-[cellular-retinol-binding-protein]
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 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.135 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.135 Bowman's capsule in the glomeruli of normal, neoplastic kidney sections Homo sapiens
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2.3.1.135 epithelium of renal tubules Homo sapiens
-
2.3.1.135 kidney
-
 Homo sapiens
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2.3.1.135 kidney tumor cell
-
 Homo sapiens
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2.3.1.135 additional information renal tissue expression pattern, expression is higher in renal tumor than in normal tissue Homo sapiens
-
2.3.1.135 renal cell carcinoma cell metastatic Homo sapiens
-
2.3.1.135 renal glomerulus
-
 Homo sapiens
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2.3.1.135 renal tubule epithelial cells Homo sapiens
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.135 phosphatidylcholine + retinol-[cellular-retinol-binding-protein]
-
 Homo sapiens 2-acylglycerophosphocholine + retinyl-ester-[cellular-retinol-binding-protein]
-
 ?
2.3.1.135 phosphatidylcholine + retinol-[cellular-retinol-binding-protein] renal cell carcinomata contain greatly reduced levels of retinol and retinyl esters relative to healthy kidney tissue Homo sapiens 2-acylglycerophosphocholine + retinyl-ester-[cellular-retinol-binding-protein]
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.135 lecithin:retinol acyltransferase
-
 Homo sapiens
2.3.1.135 LRAT
-
 Homo sapiens