BRENDA - Enzyme Database show

Glutathione modulates recombinant rat arsenic (+3 oxidation state) methyltransferase-catalyzed formation of trimethylarsine oxide and trimethylarsine

Waters, S.B.; Devesa, V.; Fricke, M.W.; Creed, J.T.; Styblo, M.; Thomas, D.J.; Chem. Res. Toxicol. 17, 1621-1629 (2004)

Data extracted from this reference:

Activating Compound
EC Number
Activating Compound
Commentary
Organism
Structure
2.1.1.137
GSH
stimulatory effect on the rate of methylarsonate and dimethylarsinate production from arsenite is concentration-dependent, suppression of formation of trimethylarsine oxide
Rattus norvegicus
Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
2.1.1.137
GSH
suppression of formation of trimethylarsine oxide, stimulatory effect on the rate of methylarsonate and dimethylarsinate production from arsenite is concentration-dependent
Rattus norvegicus
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
2.1.1.137
Rattus norvegicus
Q8VHT6
-
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.1.1.137
S-adenosyl-L-methionine + arsenite
-
658444
Rattus norvegicus
S-adenosyl-L-homocysteine + methylarsonate
-
-
-
?
2.1.1.137
S-adenosyl-L-methionine + methylarsonite
-
658444
Rattus norvegicus
S-adenosyl-L-homocysteine + dimethylarsinate
-
-
-
?
Activating Compound (protein specific)
EC Number
Activating Compound
Commentary
Organism
Structure
2.1.1.137
GSH
stimulatory effect on the rate of methylarsonate and dimethylarsinate production from arsenite is concentration-dependent, suppression of formation of trimethylarsine oxide
Rattus norvegicus
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
2.1.1.137
GSH
suppression of formation of trimethylarsine oxide, stimulatory effect on the rate of methylarsonate and dimethylarsinate production from arsenite is concentration-dependent
Rattus norvegicus
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.1.1.137
S-adenosyl-L-methionine + arsenite
-
658444
Rattus norvegicus
S-adenosyl-L-homocysteine + methylarsonate
-
-
-
?
2.1.1.137
S-adenosyl-L-methionine + methylarsonite
-
658444
Rattus norvegicus
S-adenosyl-L-homocysteine + dimethylarsinate
-
-
-
?