BRENDA - Enzyme Database show

Selenium compounds modulate the activity of recombinant rat AsIII-methyltransferase and the methylation of arsenite by rat and human hepatocytes

Walton, F.S.; Waters, S.B.; Jolley, S.L.; LeCluyse, E.L.; Thomas, D.J.; Styblo, M.; Chem. Res. Toxicol. 16, 261-265 (2003)

Data extracted from this reference:

Activating Compound
EC Number
Activating Compound
Commentary
Organism
Structure
2.1.1.137
dimethylselenoxide
weak activator of recombinant As(III)-methyltransferase, weak inhibitor of arsenite methylation in hepatocytes
Homo sapiens
2.1.1.137
dimethylselenoxide
weak activator of recombinant As(III)-methyltransferase, weak inhibitor of arsenite methylation in hepatocytes
Rattus norvegicus
2.1.1.137
trimethyl-selenonium iodide
weak activator of recombinant As(III)-methyltransferase, weak inhibitor of arsenite methylation in hepatocytes
Homo sapiens
2.1.1.137
trimethylselenonium iodide
weak activator of recombinant As(III)-methyltransferase, weak inhibitor of arsenite methylation in hepatocytes
Rattus norvegicus
Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
2.1.1.137
dimethylselenoxide
weak activator of recombinant As(III)-methyltransferase, weak inhibitor of arsenite methylation in hepatocytes
Homo sapiens
2.1.1.137
dimethylselenoxide
weak activator of recombinant As(III)-methyltransferase, weak inhibitor of arsenite methylation in hepatocytes
Rattus norvegicus
2.1.1.137
methylselenic acid
-
Homo sapiens
2.1.1.137
methylselenic acid
-
Rattus norvegicus
2.1.1.137
Sodium selenite
-
Homo sapiens
2.1.1.137
Sodium selenite
-
Rattus norvegicus
2.1.1.137
trimethyl-selenonium iodide
weak activator of recombinant As(III)-methyltransferase, weak inhibitor of arsenite methylation in hepatocytes
Homo sapiens
2.1.1.137
trimethylselenonium iodide
weak activator of recombinant As(III)-methyltransferase, weak inhibitor of arsenite methylation in hepatocytes
Rattus norvegicus
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
2.1.1.137
Homo sapiens
-
-
-
2.1.1.137
Rattus norvegicus
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
2.1.1.137
hepatocyte
-
Homo sapiens
-
2.1.1.137
hepatocyte
-
Rattus norvegicus
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.1.1.137
S-adenosyl-L-methionine + arsenite
-
658442
Homo sapiens
S-adenosyl-L-homocysteine + methylarsonate
-
-
-
?
2.1.1.137
S-adenosyl-L-methionine + arsenite
-
658442
Rattus norvegicus
S-adenosyl-L-homocysteine + methylarsonate
-
-
-
?
2.1.1.137
S-adenosyl-L-methionine + methylarsonite
-
658442
Homo sapiens
S-adenosyl-L-homocysteine + dimethylarsinate
-
-
-
?
2.1.1.137
S-adenosyl-L-methionine + methylarsonite
-
658442
Rattus norvegicus
S-adenosyl-L-homocysteine + dimethylarsinate
-
-
-
?
Ki Value [mM]
EC Number
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
2.1.1.137
0.0014
-
Sodium selenite
-
Rattus norvegicus
2.1.1.137
0.0194
-
methylselenic acid
-
Rattus norvegicus
Activating Compound (protein specific)
EC Number
Activating Compound
Commentary
Organism
Structure
2.1.1.137
dimethylselenoxide
weak activator of recombinant As(III)-methyltransferase, weak inhibitor of arsenite methylation in hepatocytes
Homo sapiens
2.1.1.137
dimethylselenoxide
weak activator of recombinant As(III)-methyltransferase, weak inhibitor of arsenite methylation in hepatocytes
Rattus norvegicus
2.1.1.137
trimethyl-selenonium iodide
weak activator of recombinant As(III)-methyltransferase, weak inhibitor of arsenite methylation in hepatocytes
Homo sapiens
2.1.1.137
trimethylselenonium iodide
weak activator of recombinant As(III)-methyltransferase, weak inhibitor of arsenite methylation in hepatocytes
Rattus norvegicus
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
2.1.1.137
dimethylselenoxide
weak activator of recombinant As(III)-methyltransferase, weak inhibitor of arsenite methylation in hepatocytes
Homo sapiens
2.1.1.137
dimethylselenoxide
weak activator of recombinant As(III)-methyltransferase, weak inhibitor of arsenite methylation in hepatocytes
Rattus norvegicus
2.1.1.137
methylselenic acid
-
Homo sapiens
2.1.1.137
methylselenic acid
-
Rattus norvegicus
2.1.1.137
Sodium selenite
-
Homo sapiens
2.1.1.137
Sodium selenite
-
Rattus norvegicus
2.1.1.137
trimethyl-selenonium iodide
weak activator of recombinant As(III)-methyltransferase, weak inhibitor of arsenite methylation in hepatocytes
Homo sapiens
2.1.1.137
trimethylselenonium iodide
weak activator of recombinant As(III)-methyltransferase, weak inhibitor of arsenite methylation in hepatocytes
Rattus norvegicus
Ki Value [mM] (protein specific)
EC Number
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
2.1.1.137
0.0014
-
Sodium selenite
-
Rattus norvegicus
2.1.1.137
0.0194
-
methylselenic acid
-
Rattus norvegicus
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
2.1.1.137
hepatocyte
-
Homo sapiens
-
2.1.1.137
hepatocyte
-
Rattus norvegicus
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.1.1.137
S-adenosyl-L-methionine + arsenite
-
658442
Homo sapiens
S-adenosyl-L-homocysteine + methylarsonate
-
-
-
?
2.1.1.137
S-adenosyl-L-methionine + arsenite
-
658442
Rattus norvegicus
S-adenosyl-L-homocysteine + methylarsonate
-
-
-
?
2.1.1.137
S-adenosyl-L-methionine + methylarsonite
-
658442
Homo sapiens
S-adenosyl-L-homocysteine + dimethylarsinate
-
-
-
?
2.1.1.137
S-adenosyl-L-methionine + methylarsonite
-
658442
Rattus norvegicus
S-adenosyl-L-homocysteine + dimethylarsinate
-
-
-
?