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Literature summary extracted from

  • Boutin, J.A.; Chatelein-Egger, F.; Vella, F.; Delagrange, P.; Ferry, G.
    Quinone reductase 2 substrate specificity and inhibitgion pharmacology (2005), Chem. Biol. Interact., 151, 213-228.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.10.5.1 5-hydroxyflavone IC50: 340 nM Homo sapiens
1.10.5.1 apigenin IC50: 430 nM Homo sapiens
1.10.5.1 chrysin-dimethylether IC50: 0.0013 mM Homo sapiens
1.10.5.1 chrysoeriol IC50: 300 nM Homo sapiens
1.10.5.1 genistein
-
 Homo sapiens
1.10.5.1 isorhamnetin IC50: 860 nM Homo sapiens
1.10.5.1 kaempferol IC50: 380 nM Homo sapiens
1.10.5.1 luteolin IC50: 780 nM Homo sapiens
1.10.5.1 quercetin IC50: 0.0014 mM Homo sapiens
1.10.5.1 quercetin-3-O-beta-glucopyranosyl IC50: 0.0015 mM Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.10.5.1 0.0067
-
 menadione
-
 Homo sapiens
1.10.5.1 0.02
-
 N-benzyldihydronicotinamide
-
 Homo sapiens
1.10.5.1 2
-
 tetrahydrofolate
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.10.5.1 cytosol
-
 Homo sapiens 5829
-

Organism

EC Number Organism UniProt Comment Textmining
1.10.5.1 Homo sapiens
-
 expressed in CHO cells
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.10.5.1 N-benzyldihydronicotinamide + coenzyme Q0
-
 Homo sapiens ?
-
 ?
1.10.5.1 N-benzyldihydronicotinamide + menadione
-
 Homo sapiens ?
-
 ?
1.10.5.1 N-benzylnicotinamide + menadiol
-
 Homo sapiens ?
-
 ?
1.10.5.1 N-ribosylnicotinamide + menadiol N-ribosylnicotinamide is a poor substrate Homo sapiens ?
-
 ?
1.10.5.1 tetrahydrofolate + menadiol
-
 Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.10.5.1 quinone reductase 2
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.10.5.1 FAD
-
 Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.10.5.1 0.0003
-
 IC50: 300 nM Homo sapiens chrysoeriol
1.10.5.1 0.00034
-
 IC50: 340 nM Homo sapiens 5-hydroxyflavone
1.10.5.1 0.00038
-
 IC50: 380 nM Homo sapiens kaempferol
1.10.5.1 0.00043
-
 IC50: 430 nM Homo sapiens apigenin
1.10.5.1 0.00078
-
 IC50: 780 nM Homo sapiens luteolin
1.10.5.1 0.00086
-
 IC50: 860 nM Homo sapiens isorhamnetin
1.10.5.1 0.0013
-
 IC50: 0.0013 mM Homo sapiens chrysin-dimethylether
1.10.5.1 0.0014
-
 IC50: 0.0014 mM Homo sapiens quercetin
1.10.5.1 0.0015
-
 IC50: 0.0015 mM Homo sapiens quercetin-3-O-beta-glucopyranosyl