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Literature summary extracted from

  • Mukherji, M.; Kershaw, N.J.; Schofield, C.J.; Wierzbicki, A.S.; Lloyd, M.D.
    Utilization of sterol carrier protein-2 by phytanoyl-CoA 2-hydroxylase in the peroxisomal alpha oxidation of phytanic acid (2002), Chem. Biol., 9, 597-605.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.14.11.18 SCP-2 phytanoylis efficiently 2-hydroxylated by PAHX in vitro in the presence of mature SCO-2. SCP-2 increases discrimination between straight-chain and branched-chain substrates, i.e. it decreases activity with straight chain substrates and increase activity with branched-chain substrates. In vivo substrates for PAHX may be SCP-2 complexes Homo sapiens

Application

EC Number Application Comment Organism
1.14.11.18 diagnostics the substrate phytanoyl-CoA is difficult to handle because of its amphipathic properties. Commercially available alternative substrates, such as hexadecanoyl-CoA or isovaleryl-CoA are potentially usefull Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.14.11.18 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.11.18 butanoyl-CoA + 2-oxoglutarate + O2
-
 Homo sapiens 2-hydroxybutanoyl-CoA + succinate + CO2
-
 ?
1.14.11.18 decanoyl-CoA + 2-oxoglutarate + O2
-
 Homo sapiens 2-hydroxydecanoyl-CoA + succinate + CO2
-
 ?
1.14.11.18 dodecanoyl-CoA + 2-oxoglutarate + O2
-
 Homo sapiens 2-hydroxydodecanoyl-CoA + succinate + CO2
-
 ?
1.14.11.18 hexadecanoyl-CoA + 2-oxoglutarate + O2
-
 Homo sapiens 2-hydroxyhexadecanoyl-CoA + succinate + CO2
-
 ?
1.14.11.18 hexanoyl-CoA + 2-oxoglutarate + O2
-
 Homo sapiens 2-hydroxyhexanoyl-CoA + succinate + CO2
-
 ?
1.14.11.18 isovaleryl-CoA + 2-oxoglutarate + O2
-
 Homo sapiens ?
-
 ?
1.14.11.18 octadecanoyl-CoA + 2-oxoglutarate + O2
-
 Homo sapiens 2-hydroxyoctadecanoyl-CoA + succinate + CO2
-
 ?
1.14.11.18 octanoyl-CoA + 2-oxoglutarate + O2
-
 Homo sapiens 2-hydroxyoctanoyl-CoA + succinate + CO2
-
 ?
1.14.11.18 phytanoyl-CoA + 2-oxoglutarate + O2
-
 Homo sapiens 2-hydroxyphytanoyl-CoA + succinate + CO2
-
 ?
1.14.11.18 tetradecanoyl-CoA + 2-oxoglutarate + O2
-
 Homo sapiens 2-hydroxytetradecanoyl-CoA + succinate + CO2
-
 ?