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Literature summary extracted from

  • Yano, S.; Kazuno, H.; Suzuki, N.; Emura, T.; Wierzba, K.; Yamashita, J.; Tada, Y.; Yamada, Y.; Fukushima, M.; Asao, T.
    Synthesis and evaluation of 6-methylene-bridged uracil derivatives. Part 1: discovery of novel orally active inhibitors of human thymidine phosphorylase (2004), Bioorg. Med. Chem., 12, 3431-3441.
    View publication on PubMed

Organism

EC Number Organism UniProt Comment Textmining
2.4.2.3 Bos taurus
-
 cattle
-
2.4.2.3 Equus caballus
-
-
-
2.4.2.3 Homo sapiens
-
-
-
2.4.2.3 Mus musculus
-
-
-
2.4.2.3 Ovis aries
-
-
-
2.4.2.3 Rattus norvegicus
-
-
-
2.4.2.3 Sus scrofa
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.2.3 bone marrow
-
 Mus musculus
-
2.4.2.3 bone marrow
-
 Rattus norvegicus
-
2.4.2.3 colon
-
 Homo sapiens
-
2.4.2.3 colonic cancer cell
-
 Homo sapiens
-
2.4.2.3 colonic cancer cell colon tumor 38 Mus musculus
-
2.4.2.3 colonic cancer cell RPMI colon tumor Rattus norvegicus
-
2.4.2.3 embryonic stem cell high activity Mus musculus
-
2.4.2.3 intestine high activity Mus musculus
-
2.4.2.3 kidney
-
 Mus musculus
-
2.4.2.3 L-5178-Y cell
-
 Mus musculus
-
2.4.2.3 liver
-
 Mus musculus
-
2.4.2.3 liver
-
 Homo sapiens
-
2.4.2.3 lung
-
 Homo sapiens
-
2.4.2.3 lung adenocarcinoma cell
-
 Homo sapiens
-
2.4.2.3 lymphocyte peripheral Bos taurus
-
2.4.2.3 lymphocyte peripheral, very low activity Homo sapiens
-
2.4.2.3 lymphocyte peripheral, very low activity Sus scrofa
-
2.4.2.3 lymphocyte peripheral, very low activity Ovis aries
-
2.4.2.3 lymphocyte peripheral, very low activity Equus caballus
-
2.4.2.3 placenta
-
 Homo sapiens
-
2.4.2.3 spleen
-
 Mus musculus
-
2.4.2.3 squamous cell carcinoma cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.3 fluorouridine + phosphate
-
 Mus musculus fluorouracil + alpha-D-ribose-1-phosphate
-
 ?
2.4.2.3 fluorouridine + phosphate
-
 Rattus norvegicus fluorouracil + alpha-D-ribose-1-phosphate
-
 ?
2.4.2.3 uridine + phosphate
-
 Mus musculus uracil + alpha-D-ribose 1-phosphate
-
 ?
2.4.2.3 uridine + phosphate
-
 Homo sapiens uracil + alpha-D-ribose 1-phosphate
-
 ?
2.4.2.3 uridine + phosphate
-
 Rattus norvegicus uracil + alpha-D-ribose 1-phosphate
-
 ?
2.4.2.3 uridine + phosphate
-
 Sus scrofa uracil + alpha-D-ribose 1-phosphate
-
 ?
2.4.2.3 uridine + phosphate
-
 Bos taurus uracil + alpha-D-ribose 1-phosphate
-
 ?
2.4.2.3 uridine + phosphate
-
 Ovis aries uracil + alpha-D-ribose 1-phosphate
-
 ?
2.4.2.3 uridine + phosphate
-
 Equus caballus uracil + alpha-D-ribose 1-phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.2.3 UPase
-
 Mus musculus
2.4.2.3 UPase
-
 Homo sapiens
2.4.2.3 UPase
-
 Rattus norvegicus
2.4.2.3 UPase
-
 Sus scrofa
2.4.2.3 UPase
-
 Bos taurus
2.4.2.3 UPase
-
 Ovis aries
2.4.2.3 UPase
-
 Equus caballus