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Literature summary extracted from
- Functional significance of the pentose phosphate pathway and glutathione reductase in the antioxidant defenses of human sperm (2004), Biol. Reprod., 71, 1309-1316.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.8.1.7 | additional information | oxidative agents, e.g. cumene hydroperoxide or xanthine, increase the flux through the pentose phosphate pathway and enzyme activity | Homo sapiens |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.8.1.7 | 1,3-bis-(2-chloroethyl) 1-nitrosourea | physiological effects of enzyme inhibition in spermatozoa are increase of lipid peroxidation and impairment of sperm motility | Homo sapiens |  |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.8.1.7 | glutathione disulfide + NADPH | Homo sapiens | enzyme produces glutathione in spermatozoa which is required for reduction and antioxidant defense by glutathione peroxidase, enzyme is involved in protection of the cells against oxidative damage, regulatory of pentose phosphate pathway, pathway overview | glutathione + NADP+ | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.8.1.7 | Homo sapiens | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.8.1.7 | sperm | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.8.1.7 | glutathione disulfide + NADPH | - |
Homo sapiens | glutathione + NADP+ | - |
? | |
| 1.8.1.7 | glutathione disulfide + NADPH | enzyme produces glutathione in spermatozoa which is required for reduction and antioxidant defense by glutathione peroxidase, enzyme is involved in protection of the cells against oxidative damage, regulatory of pentose phosphate pathway, pathway overview | Homo sapiens | glutathione + NADP+ | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.8.1.7 | glutathione reductase | - |
Homo sapiens |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.8.1.7 | NADPH | from pentose phosphate pathway | Homo sapiens | |
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Release 2023.1 (January 2023)
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