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Literature summary extracted from

  • Nordman, T.; Xia, L.; Bjorkhem-Bergman, L.; Damdimopoulos, A.; Nalvarte, I.; Arner, E.S.; Spyrou, G.; Eriksson, L.C.; Bjornstedt, M.; Olsson, J.M.
    Regeneration of the antioxidant ubiquinol by lipoamide dehydrogenase, thioredoxin reductase and glutathione reductase (2003), Biofactors, 18, 45-50.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.8.1.4 cytosol
-
 Sus scrofa 5829
-
1.8.1.4 microsome
-
 Sus scrofa
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.8.1.4 Zn2+ highly stimulating for ubiquinone reduction Sus scrofa

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.8.1.4 55000
-
 2 * 55000, about, SDS-PAGE Sus scrofa
1.8.1.4 115000
-
 gel filtration Sus scrofa

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.8.1.4 ubiquinone + NAD(P)H Sus scrofa enzyme is involved in extramitochondrial regeneration of the important antioxidant ubiquinol required for cell protection against peroxidation ubiquinol + NAD(P)+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.8.1.4 Sus scrofa
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.8.1.4 commercial preparation
-
 Sus scrofa
-
1.8.1.4 heart
-
 Sus scrofa
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.8.1.4 ubiquinone + NAD(P)H
-
 Sus scrofa ubiquinol + NAD(P)+
-
 ?
1.8.1.4 ubiquinone + NAD(P)H enzyme is involved in extramitochondrial regeneration of the important antioxidant ubiquinol required for cell protection against peroxidation Sus scrofa ubiquinol + NAD(P)+
-
 ?

Subunits

EC Number Subunits Comment Organism
1.8.1.4 dimer 2 * 55000, about, SDS-PAGE Sus scrofa

Synonyms

EC Number Synonyms Comment Organism
1.8.1.4 DT-diaphorase
-
 Sus scrofa
1.8.1.4 LipDH
-
 Sus scrofa
1.8.1.4 lipoamide dehydrogenase
-
 Sus scrofa

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.8.1.4 additional information
-
 highest activity at acidic pH Sus scrofa

Cofactor

EC Number Cofactor Comment Organism Structure
1.8.1.4 FAD flavoenzyme, 1 FAD per enzyme subunit, functionally important Sus scrofa
1.8.1.4 additional information enzyme contains 1 disulfide/dithiol per subunit Sus scrofa
1.8.1.4 NAD(P)H NADPH and NADH are equally effective as cofactors Sus scrofa