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Literature summary extracted from

  • Molnar, J.; Fong, K.S.K.; He, Q.P.; Hayashi, K.; Kim, Y.; Fong, S.F.T.; Fogelgren, B.; Molnarne Szauter, K.; Mink, M.; Csiszar, K.
    Structural and functional diversity of lysyl oxidase and the LOX-like proteins (2003), Biochim. Biophys. Acta, 1647, 220-224.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.4.3.13 beta-aminopropionitrile inhibition of LOXL-1 Drosophila melanogaster
1.4.3.13 beta-aminopropionitrile selective inhibition of mammalian LOX Homo sapiens
1.4.3.13 beta-aminopropionitrile selective inhibition of mammalian LOX Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.4.3.13 extracellular matrix LOX, LOXL Homo sapiens 31012
-
1.4.3.13 additional information lysyl oxidase and 4 LOX-like proteins LOXL, LOXL2, LOXL3, and LOXL4 show individual, developmentally regulated tissue and cell-specific expression and localization Mus musculus
-
-
1.4.3.13 additional information lysyl oxidase and 4 LOX-like proteins LOXL, LOXL2, LOXL3, and LOXL4 show individual, developmentally regulated tissue and cell-specific expression and localization Homo sapiens
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.4.3.13 Cu2+ copper-cofactor, lysyl oxidase and LOX-like proteins LOXL-1 and LOXL-2, conserved binding domain Drosophila melanogaster
1.4.3.13 Cu2+ lysyl oxidase and LOX-like proteins LOXL, LOXL2, LOXL3, and LOXL4 Mus musculus
1.4.3.13 Cu2+ lysyl oxidase and LOX-like proteins LOXL, LOXL2, LOXL3, and LOXL4 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.4.3.13 additional information Homo sapiens LOX induced chromatin changes, mechanism via histone deamination ?
-
?
1.4.3.13 additional information Drosophila melanogaster LOX induced chromatin changes, mechanism via histone deamination ?
-
?
1.4.3.13 peptidyl-L-lysyl-peptide + O2 + H2O Mus musculus
-
peptidyl-allysyl-peptide + NH3 + H2O2
-
?
1.4.3.13 peptidyl-L-lysyl-peptide + O2 + H2O Homo sapiens
-
peptidyl-allysyl-peptide + NH3 + H2O2
-
?
1.4.3.13 peptidyl-L-lysyl-peptide + O2 + H2O Drosophila melanogaster
-
peptidyl-allysyl-peptide + NH3 + H2O2
-
?

Organism

EC Number Organism UniProt Comment Textmining
1.4.3.13 Drosophila melanogaster Q9N9Y8 LOXL-2; lysyl oxidase and 2 LOX-like proteins LOXL and LOXL2
-
1.4.3.13 Drosophila melanogaster Q9V9X5 LOXL-1; lysyl oxidase and 2 LOX-like proteins LOXL and LOXL2
-
1.4.3.13 Homo sapiens
-
structurally and functionally diverse enzyme forms: lysyl oxidase and 4 LOX-like proteins LOXL, LOXL2, LOXL3, and LOXL4, probably existing splicing variants of LOXL3
-
1.4.3.13 Mus musculus
-
adult B6SJLF1 mice, structurally and functionally diverse enzyme forms: lysyl oxidase and 4 LOX-like proteins LOXL, LOXL2, LOXL3, and LOXL4, probably existing splicing variants of LOXL3
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
1.4.3.13 proteolytic modification N-terminal processing by BMP-1 of lysyl oxidase and LOX-like proteins LOXL, LOXL2, LOXL3, and LOXL4 in the extracellular matrix results in active proteins Mus musculus
1.4.3.13 proteolytic modification N-terminal processing by BMP-1 of lysyl oxidase and LOX-like proteins LOXL, LOXL2, LOXL3, and LOXL4 in the extracellular matrix results in active proteins Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.4.3.13 aorta LOX, LOXL, LOXL3, low expression level of LOXL2 Homo sapiens
-
1.4.3.13 embryo LOXL-1 Drosophila melanogaster
-
1.4.3.13 embryo LOXL-1, no expression of LOXL-2 Drosophila melanogaster
-
1.4.3.13 heart only in fetal heart, LOXL2, very low expression level of LOXL3 Homo sapiens
-
1.4.3.13 kidney LOXL4, LOX, LOXL Homo sapiens
-
1.4.3.13 larva LOXL-1 Drosophila melanogaster
-
1.4.3.13 larva LOXL-1, no expression of LOXL-2 Drosophila melanogaster
-
1.4.3.13 lung LOXL4, LOX, LOXL Homo sapiens
-
1.4.3.13 additional information adult fly: LOXL and LOXL-2, the latter occurs exclusively in adult flies, developmental expression analysis of LOX-like proteins LOXL and LOXL2 in embryos, larvae, pupae, and adult flies, no expression of LOXL-2 in larvae, pupae, and embryos, overview Drosophila melanogaster
-
1.4.3.13 additional information adult fly: LOXL and LOXL-2, the latter occurs exclusively in adult flies, developmental expression analysis of LOX-like proteins LOXL and LOXL2 in embryos, larvae, pupae, and adult flies, overview Drosophila melanogaster
-
1.4.3.13 additional information lysyl oxidase and 4 LOX-like proteins LOXL, LOXL2, LOXL3, and LOXL4 show individual, developmentally regulated tissue and cell-specific expression and localization Mus musculus
-
1.4.3.13 additional information lysyl oxidase and 4 LOX-like proteins LOXL, LOXL2, LOXL3, and LOXL4 show individual, developmentally regulated tissue and cell-specific expression and localization, expression patterns, LOX and LOXL are expressed in most tissues Homo sapiens
-
1.4.3.13 ovary LOXL4, LOX, LOXL Homo sapiens
-
1.4.3.13 pancreas LOXL4, LOX, LOXL Homo sapiens
-
1.4.3.13 placenta LOXL4, LOXL2, LOX, LOXL Homo sapiens
-
1.4.3.13 prostate LOXL2, LOX, LOXL Homo sapiens
-
1.4.3.13 pupa LOXL-1 Drosophila melanogaster
-
1.4.3.13 pupa LOXL-1, no expression of LOXL-2 Drosophila melanogaster
-
1.4.3.13 testis LOXL4, LOX, LOXL Homo sapiens
-
1.4.3.13 uterus LOXL2, LOX, LOXL Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.4.3.13 additional information LOX induced chromatin changes, mechanism via histone deamination Homo sapiens ?
-
?
1.4.3.13 additional information LOX induced chromatin changes, mechanism via histone deamination Drosophila melanogaster ?
-
?
1.4.3.13 additional information lysyl oxidase and 4 LOX-like proteins LOXL, LOXL2, LOXL3, and LOXL4 all contain a cytokine receptor-like domain Mus musculus ?
-
?
1.4.3.13 additional information lysyl oxidase and 4 LOX-like proteins LOXL, LOXL2, LOXL3, and LOXL4 all contain a cytokine receptor-like domain Homo sapiens ?
-
?
1.4.3.13 peptidyl-L-lysyl-peptide + O2 + H2O
-
Mus musculus peptidyl-allysyl-peptide + NH3 + H2O2
-
?
1.4.3.13 peptidyl-L-lysyl-peptide + O2 + H2O
-
Homo sapiens peptidyl-allysyl-peptide + NH3 + H2O2
-
?
1.4.3.13 peptidyl-L-lysyl-peptide + O2 + H2O
-
Drosophila melanogaster peptidyl-allysyl-peptide + NH3 + H2O2
-
?

Subunits

EC Number Subunits Comment Organism
1.4.3.13 More domain structure of LOX-like protein Drosophila melanogaster
1.4.3.13 More domain structure of LOX-like protein, LOXL-1 and LOXL-2 contain SRCR domains Drosophila melanogaster
1.4.3.13 More the enzymes contain SRCR domains Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
1.4.3.13 LOX
-
Mus musculus
1.4.3.13 LOX
-
Homo sapiens
1.4.3.13 LOX
-
Drosophila melanogaster
1.4.3.13 LOX-like protein
-
Drosophila melanogaster
1.4.3.13 LOXL
-
Mus musculus
1.4.3.13 LOXL
-
Homo sapiens
1.4.3.13 LOXL
-
Drosophila melanogaster
1.4.3.13 lysyl oxidase
-
Mus musculus
1.4.3.13 lysyl oxidase
-
Homo sapiens
1.4.3.13 lysyl oxidase
-
Drosophila melanogaster
1.4.3.13 lysyl oxidase-like protein
-
Mus musculus
1.4.3.13 lysyl oxidase-like protein
-
Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.4.3.13 quinone lysyl oxidase and 4 LOX-like proteins LOXL, LOXL2, LOXL3, and LOXL4 all contain conserved lysyl and tyrosyl residues that may contribute to quinone cofactor formation Mus musculus
1.4.3.13 quinone lysyl oxidase and 4 LOX-like proteins LOXL, LOXL2, LOXL3, and LOXL4 all contain conserved lysyl and tyrosyl residues that may contribute to quinone cofactor formation Homo sapiens