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Literature summary extracted from

  • Gilep, A.A.; Estabrook, R.W.; Usanov, S.A.
    Chimerogenesis in estimation of specificity and pathway directions for cytochrome P45017alpha catalyzed reactions (2004), Biochemistry (Moscow), 69, 364-375.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
1.14.14.19 additional information chimeric constructions of enzyme from Bos taurus and from Cavia porcellus, structural element responsible for switching activity between DELTA4- or DELTA5-pathway is located in the region of polypeptide chain coded by exons II-V of CYP17 gene Cavia porcellus
1.14.14.32 additional information chimeric constructions of enzyme from Bos taurus and from Cavia porcellus, structural element responsible for switching activity between DELTA4- or DELTA5-pathway is located in the region of polypeptide chain coded by exons II-V of CYP17 gene Cavia porcellus

Organism

EC Number Organism UniProt Comment Textmining
1.14.14.19 Cavia porcellus Q64410
-
-
1.14.14.32 Cavia porcellus Q64410
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.14.19 additional information enzyme effectively catalyzes hydroxylation reaction for both progesterone and pregnenolone, with 17alpha-hydroxyprogesterone, also 17,20-lyase activity is realized Cavia porcellus ?
-
 ?
1.14.14.19 pregnenolone + AH2 + O2
-
 Cavia porcellus 17alpha-hydroxypregnenolone + A + H2O
-
 ?
1.14.14.19 progesterone + [reduced NADPH-hemoprotein reductase] + O2
-
 Cavia porcellus 17alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.32 17alpha-hydroxyprogesterone + ?
-
 Cavia porcellus androstenedione + ?
-
 ?
1.14.14.32 additional information enzyme catalyzes both 17alpha-hydroxylation of steroids, EC 1.14.99.9, and 17,20-lyase reaction, lyase activity is realized only with 17alpha-hydroxyprogesterone Cavia porcellus ?
-
 ?