Literature summary extracted from

Zakharova, N.V.; Zharova, T.V.
Kinetic mechanism of mitochondrial NADH:ubiquinone oxidoreductase interaction with nucleotide substrates of the transhydrogenase reaction (2002), Biochemistry, 67, 1395-1404.

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
7.1.1.2	5BM-GX	inhibits transhydrogenation reaction with NADH and 3'-acetyl pyridine adenine dinucleotide	Bos taurus
7.1.1.2	AMS-GX	inhibits transhydrogenation reaction with NADH and 3'-acetyl pyridine adenine dinucleotide	Bos taurus

KM Value [mM]

EC Number	KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
7.1.1.2	0.0004	-	deamino-NADH	pH 8.0, 26°C	Bos taurus
7.1.1.2	0.0027	-	NADH	pH 8.0, 26°C	Bos taurus
7.1.1.2	0.125	-	3'-acetyl pyridine adenine dinucleotide	pH 8.0, 26°C	Bos taurus

Localization

EC Number	Localization	Comment	Organism	GeneOntology No.	Textmining
7.1.1.2	mitochondrion	-	Bos taurus	5739	-

Organism

EC Number	Organism	UniProt	Comment	Textmining
7.1.1.2	Bos taurus	-	-	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
7.1.1.2	deamino-NADH + ubiquinone + H+[side 1]	-	Bos taurus	deamino-NAD+ + ubiquinol + H+[side 2]	-	?
7.1.1.2	NADH + 3'-acetyl pyridine adenine dinucleotide	-	Bos taurus	NAD+ + ?	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
7.1.1.2	NADH:ubiquinone oxidoreductase	-	Bos taurus

Cofactor

EC Number	Cofactor	Comment	Organism	Structure
7.1.1.2	NADH	-	Bos taurus

Ki Value [mM]

EC Number	Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
7.1.1.2	0.001	-	AMS-GX	-	Bos taurus
7.1.1.2	0.005	-	5BM-GX	-	Bos taurus

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Release 2023.1 (January 2023)