Literature summary extracted from

Shao, J.; Zhou, B.; Zhu, L.; Bilio, A.J.; Su, L.; Yuan, Y.C.; Ren, S.; Lien, E.J.; Shih, J.; Yen, Y.
Determination of the potency and subunit-selectivity of ribonucleotide reductase inhibitors with a recombinant-holoenzyme-based in vitro assay (2005), Biochem. Pharmacol., 69, 627-634.

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
1.17.4.1	deferoxamine mesylate	IC50 for subunit p53R2 is 0.00316 mM, IC50 for hRRM2 subunit is 0.5 mM	Homo sapiens
1.17.4.1	Hydroxyurea	IC50 for subunit p53R2 is 2.48 mM, IC50 for hRRM2 subunit is 0.991 mM	Homo sapiens
1.17.4.1	triapine	IC50 for subunit p53R2 is 112 nM, IC50 for hRRM2 subunit is 144 nM	Homo sapiens

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.17.4.1	Homo sapiens	-	-	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1.17.4.1	CDP + reduced thioredoxin	-	Homo sapiens	2'-dCDP + thioredoxin disulfide + H2O	-	?

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Release 2023.1 (January 2023)