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Literature summary extracted from

  • Forsgren, M.; Attersand, A.; Lake, S.; Gruenler, J.; Swiezewska, E.; Dallner, G.; Climent, I.
    Isolation and functional expression of human COQ2, a gene encoding a polyprenyl transferase involved in the synthesis of CoQ (2004), Biochem. J., 382, 519-526.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.5.1.39 gene COQ2, complementation of yeast Coq2 null mutant cells Saccharomyces cerevisiae
2.5.1.39 gene COQ2, DNA and amino acid sequence determination and analysis, functional expression in and complementation of yeast Coq2 null mutant cells, CoQ biosynthesis rate is lower in the yeast cells when rescued with the human enzyme compared to cells rescued with the yeast enzyme Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
2.5.1.39 additional information CoQ biosynthesis in yeast null mutant cells can be rescued with expression of the human enzyme at a lower rate compared to cells rescued with the yeast enzyme Saccharomyces cerevisiae

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.5.1.39 membrane the enzyme contains 6 transmembrane sequences Homo sapiens 16020
-
2.5.1.39 mitochondrion
-
 Homo sapiens 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.5.1.39 decaprenyl diphosphate + 4-hydroxybenzoate Saccharomyces cerevisiae
-
 diphosphate + decaprenyl-4-hydroxybenzoate
-
 ?
2.5.1.39 decaprenyl diphosphate + 4-hydroxybenzoate Homo sapiens
-
 diphosphate + decaprenyl-4-hydroxybenzoate
-
 ?
2.5.1.39 additional information Saccharomyces cerevisiae the enzyme is required for biosynthesis of CoQ2, i.e. ubiquinone ?
-
 ?
2.5.1.39 additional information Homo sapiens the enzyme is required for biosynthesis of CoQ2, i.e. ubiquinone ?
-
 ?
2.5.1.39 solanesyl diphosphate + 4-hydroxybenzoate Saccharomyces cerevisiae
-
 diphosphate + nonaprenyl-4-hydroxybenzoate
-
 ?
2.5.1.39 solanesyl diphosphate + 4-hydroxybenzoate Homo sapiens
-
 diphosphate + nonaprenyl-4-hydroxybenzoate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.39 Homo sapiens Q96H96
-
-
2.5.1.39 Saccharomyces cerevisiae
-
 gene COQ2
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.5.1.39 adrenal gland high enzyme expression Homo sapiens
-
2.5.1.39 brain fetal Homo sapiens
-
2.5.1.39 heart high enzyme expression Homo sapiens
-
2.5.1.39 liver
-
 Homo sapiens
-
2.5.1.39 pancreas
-
 Homo sapiens
-
2.5.1.39 skeletal muscle high enzyme expression Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.5.1.39 additional information
-
 activity in recombinant yeast cells Saccharomyces cerevisiae
2.5.1.39 additional information
-
 activity in recombinant yeast cells Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.39 decaprenyl diphosphate + 4-hydroxybenzoate
-
 Saccharomyces cerevisiae diphosphate + decaprenyl-4-hydroxybenzoate
-
 ?
2.5.1.39 decaprenyl diphosphate + 4-hydroxybenzoate
-
 Homo sapiens diphosphate + decaprenyl-4-hydroxybenzoate
-
 ?
2.5.1.39 decaprenyl diphosphate + 4-hydroxybenzoate preferred substrate Homo sapiens diphosphate + decaprenyl-4-hydroxybenzoate
-
 ?
2.5.1.39 additional information the enzyme is required for biosynthesis of CoQ2, i.e. ubiquinone Saccharomyces cerevisiae ?
-
 ?
2.5.1.39 additional information the enzyme is required for biosynthesis of CoQ2, i.e. ubiquinone Homo sapiens ?
-
 ?
2.5.1.39 additional information the enzyme catalyzes the prenylation of 4-hydroxybenzoate with an all-trans polyprenyl group Saccharomyces cerevisiae ?
-
 ?
2.5.1.39 additional information the enzyme catalyzes the prenylation of 4-hydroxybenzoate with an all-trans polyprenyl group Homo sapiens ?
-
 ?
2.5.1.39 solanesyl diphosphate + 4-hydroxybenzoate
-
 Saccharomyces cerevisiae diphosphate + nonaprenyl-4-hydroxybenzoate
-
 ?
2.5.1.39 solanesyl diphosphate + 4-hydroxybenzoate
-
 Homo sapiens diphosphate + nonaprenyl-4-hydroxybenzoate
-
 ?

Subunits

EC Number Subunits Comment Organism
2.5.1.39 More the enzyme contains 6 transmembrane sequences and an UbiA domain Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
2.5.1.39 COQ2
-
 Homo sapiens
2.5.1.39 p-hydroxybenzoate:polyprenyl transferase
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.5.1.39 30
-
 assay at Saccharomyces cerevisiae
2.5.1.39 30
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.5.1.39 7.4
-
 assay at Saccharomyces cerevisiae
2.5.1.39 7.4
-
 assay at Homo sapiens