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Literature summary extracted from

  • Martin, C.; Bean, R.; Rose, K.; Habib, F.; Seckl, J.
    cyp7b1 catalyses the 7alpha-hydroxylation of dehydroepiandrosterone and 25-hydroxycholesterol in rat prostate (2001), Biochem. J., 355, 509-515.
    View publication on PubMedView publication on EuropePMC

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.14.14.29 0.001
-
cholest-5-ene-3beta,25-diol pH 7.4, 37°C Rattus norvegicus
1.14.14.29 0.004
-
4-androstene-3,17-dione pH 7.4, 37°C Rattus norvegicus
1.14.14.29 0.011
-
17beta-estradiol pH 7.4, 37°C Rattus norvegicus
1.14.14.29 0.014
-
dehydroepiandrosterone pH 7.4, 37°C Rattus norvegicus
1.14.14.29 0.022
-
5alpha-Androstane-3beta,17beta-diol pH 7.4, 37°C Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
1.14.14.29 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.14.29 epithelial cell of prostate Rattus norvegicus
-
1.14.14.29 prostate epithelial cell Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.14.29 17beta-estradiol + NADPH + H+ + O2
-
Rattus norvegicus 1,3,5(10)-estratrien-3,7-alpha,17beta-triol + NADP+ + H2O
-
?
1.14.14.29 4-androstene-3,17-dione + NADPH + H+ + O2
-
Rattus norvegicus 7alpha-hydroxy-4-androstene-3,17-dione + NADP+ + H2O
-
?
1.14.14.29 5alpha-androstane-3beta,17beta-diol + NADPH + H+ + O2
-
Rattus norvegicus 5alpha,androstane-3beta,7alpha,17beta-triol + NADP+ + H2O
-
?
1.14.14.29 cholest-5-ene-3beta,25-diol + NADPH + H+ + O2
-
Rattus norvegicus cholest-5-ene-3beta,7alpha,25-triol + NADP+ + H2O
-
?
1.14.14.29 dehydroepiandrosterone + NADPH + H+ + O2
-
Rattus norvegicus 3beta,7alpha-dihydroxy-5-androsten-17-one + NADP+ + H2O
-
?

Synonyms

EC Number Synonyms Comment Organism
1.14.14.29 CYP7B1
-
Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.14.29 cytochrome P-450
-
Rattus norvegicus
1.14.14.29 NADPH
-
Rattus norvegicus