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Literature summary extracted from

  • Hayakawa, T.; Kobayashi, Y.; Cui, X.; Hirano, S.
    A new metabolic pathway of arsenite: arsenic-glutathione complexes are substrates for human arsenic methyltransferase Cyt19 (2005), Arch. Toxicol., 79, 183-191.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.1.1.137 GSH nonenzymatic generation of arsenic triglutathione from arsenite when GSH is present at concentrations 2 mM or higher. Methylation of arsenic is catalyzed by Cyt19 only when arsenic triglutathione is present in the reaction mixture Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.1.1.137
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.137 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.137 additional information monomethylarsonous acid is not methylated Homo sapiens ?
-
 ?
2.1.1.137 S-adenosyl-L-methionine + arsenite
-
 Homo sapiens S-adenosyl-L-homocysteine + methylarsonate
-
 ?
2.1.1.137 S-adenosyl-L-methionine + methylarsonite
-
 Homo sapiens S-adenosyl-L-homocysteine + dimethylarsinate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.1.1.137 arsenic methyltransferase Cyt19
-
 Homo sapiens
2.1.1.137 Cyt19
-
 Homo sapiens