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Literature summary extracted from

  • Khan, N.; Sharma, K.K.; Andersson, S.; Auchus, R.J.
    Human 17beta-hydroxysteroid dehydrogenases types 1, 2, and 3 catalyze bi-directional equilibrium reactions, rather than unidirectional metabolism, in HEK-293 cells (2004), Arch. Biochem. Biophys., 429, 50-59.
    View publication on PubMed

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.51 Homo sapiens
-
-
-
1.1.1.62 Homo sapiens
-
-
-
1.1.1.64 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.51 HEK-293 cell
-
 Homo sapiens
-
1.1.1.62 HEK-293 cell
-
 Homo sapiens
-
1.1.1.64 HEK-293 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.51 androstenedione + NADPH + H+ the equilibrium state is 2% testosterone to 95% androstenedione Homo sapiens testosterone + NADP+
-
 r
1.1.1.51 estradiol + NADP+ the equilibrium state is 3% estradiol and 97% estrone Homo sapiens estrone + NADPH
-
 r
1.1.1.62 estradiol + NADP+ the equilibrium state is 92% estradiol to 8% estrone Homo sapiens estrone + NADPH
-
 ?
1.1.1.64 androstenedione + NADPH + H+ the equilibrium state is 92% testosterone to 8% androstenedione Homo sapiens testosterone + NADP+
-
 r

Synonyms

EC Number Synonyms Comment Organism
1.1.1.51 17beta-hydroxysteroid dehydrogenases type 2
-
 Homo sapiens
1.1.1.51 17betaHSD2
-
 Homo sapiens
1.1.1.62 17beta-hydroxysteroid dehydrogenases type 1
-
 Homo sapiens
1.1.1.62 17betaHSD1
-
 Homo sapiens
1.1.1.64 17beta-hydroxysteroid dehydrogenases type 3
-
 Homo sapiens
1.1.1.64 17betaHSD3
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.51 NADP+
-
 Homo sapiens
1.1.1.51 NADPH
-
 Homo sapiens
1.1.1.62 NADP+
-
 Homo sapiens
1.1.1.62 NADPH
-
 Homo sapiens
1.1.1.64 NADP+
-
 Homo sapiens
1.1.1.64 NADPH
-
 Homo sapiens