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Literature summary extracted from

  • Anusevicius, Z.; Sarlauskas, J.; Cenas, N.
    Two-electron reduction of quinones by rat liver NAD(P)H:quinone oxidoreductase: quantitative structure-activity relationships (2002), Arch. Biochem. Biophys., 404, 254-262.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.6.5.2 additional information Rattus norvegicus plays one of the main roles in the bioactivation of quinoidal drugs ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.6.5.2 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.6.5.2 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.6.5.2 1,4-benzoquinone + NADPH
-
 Rattus norvegicus 1,4-benzosemiquinone + NADP+
-
 ?
1.6.5.2 1,4-naphthoquinone + NADPH + H+
-
 Rattus norvegicus 1,4-naphthoquinol + NADP+
-
 ?
1.6.5.2 1,8-dihydroxy-9,10-anthraquinone + NADPH
-
 Rattus norvegicus 1,8-dihydroxy-9,10-anthraquinol + NADP+
-
 ?
1.6.5.2 1-hydroxy-9,10-anthraquinone + NADPH
-
 Rattus norvegicus 1-hydroxy-9,10-anthraquinol + NADP+
-
 ?
1.6.5.2 2,3-diglutathionyl-1,4-naphthoquinone + NADPH
-
 Rattus norvegicus 2,3-diglutathionyl-1,4-naphthoquinol + NADP+
-
 ?
1.6.5.2 2,5-diaziridinyl-1,4-benzoquinone + NADPH
-
 Rattus norvegicus 2,5-diaziridinyl-1,4-benzoquinol + NADP+
-
 ?
1.6.5.2 2,5-dihydroxy-1,4-naphthoquinone + NADPH
-
 Rattus norvegicus 2,5-dihydroxy-1,4-naphthoquinol + NADP+
-
 ?
1.6.5.2 2,5-dimethyl-1,4-benzoquinone + NADPH
-
 Rattus norvegicus 2,5-dimethyl-1,4-benzoquinol + NADP+
-
 ?
1.6.5.2 2,5-dimethyl-3,6-diaziridinyl-1,4-benzoquinone + NADPH
-
 Rattus norvegicus 2,5-dimethyl-3,6-diaziridinyl-1,4-benzoquinol + NADP+
-
 ?
1.6.5.2 2,6-dimethyl-1,4-benzoquinone + NADPH
-
 Rattus norvegicus 2,6-dimethyl-1,4-benzoquinol + NADP+
-
 ?
1.6.5.2 2-hydroxy-1,4-naphthoquinone + NADPH
-
 Rattus norvegicus 2-hydroxy-1,4-naphthoquinol + NADP+
-
 ?
1.6.5.2 2-methyl-1,4-benzoquinone + NADPH
-
 Rattus norvegicus 2-methyl-1,4-benzoquinol + NADP+
-
 ?
1.6.5.2 2-methyl-1,4-naphthoquinone + NADPH
-
 Rattus norvegicus 2-methyl-1,4-naphthoquinol + NADp+
-
 ?
1.6.5.2 2-methyl-3-glutathionyl-5-hydroxy-1,4-naphthoquinone + NADPH
-
 Rattus norvegicus 2-methyl-3-glutathionyl-5-hydroxy-1,4-naphthoquinol + NADP+
-
 ?
1.6.5.2 2-methyl-3-hydroxy-1,4-naphthoquinone + NADPH
-
 Rattus norvegicus 2-methyl-3-hydroxy-1,4-naphthoquinol + NADP+
-
 ?
1.6.5.2 2-methyl-5-hydroxy-1,4-naphthoquinone + NADPH
-
 Rattus norvegicus 2-methyl-5-hydroxy-1,4-naphthoquinol + NADP+
-
 ?
1.6.5.2 5,8-dihydroxy-1,4-naphthoquinone + NADPH
-
 Rattus norvegicus 5,8-dihydroxy-1,4-naphthoquinol + NADP+
-
 ?
1.6.5.2 5-hydroxy-1,4-naphthoquinone + NADPH
-
 Rattus norvegicus 5-hydroxy-1,4-naphthosemiquinone + NADP+
-
 ?
1.6.5.2 9,10-anthraquinone-2,6-disulfonate + NADPH
-
 Rattus norvegicus ? + NADP+
-
 ?
1.6.5.2 9,10-anthraquinone-2-sulfonate + NADPH
-
 Rattus norvegicus ? + NADP+
-
 ?
1.6.5.2 9,10-phenanthrene quinone + NADPH
-
 Rattus norvegicus 9,10-phenanthrene quinol + NADP+
-
 ?
1.6.5.2 mitomycin C + NADPH
-
 Rattus norvegicus ? + NADP+
-
 ?
1.6.5.2 additional information plays one of the main roles in the bioactivation of quinoidal drugs Rattus norvegicus ?
-
 ?
1.6.5.2 riboflavin + NADPH
-
 Rattus norvegicus ? + NADP+
-
 ?
1.6.5.2 tetramethyl-1,4-benzoquinone + NADPH
-
 Rattus norvegicus tetramethyl-1,4-benzoquinol + NADP+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.6.5.2 DT-diaphorase
-
 Rattus norvegicus
1.6.5.2 NAD(P)H:quinone oxidoreductase
-
 Rattus norvegicus
1.6.5.2 NQO1
-
 Rattus norvegicus

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.6.5.2 2.3
-
 9,10-anthraquinone-2,6-disulfonate pH 7.0 Rattus norvegicus
1.6.5.2 4.4
-
 2,3-diglutathionyl-1,4-naphthoquinone pH 7.0 Rattus norvegicus
1.6.5.2 26.3
-
 2-methyl-3-glutathionyl-5-hydroxy-1,4-naphthoquinone pH 7.0 Rattus norvegicus
1.6.5.2 52
-
 9,10-phenanthrene quinone pH 7.0 Rattus norvegicus
1.6.5.2 71
-
 5,8-Dihydroxy-1,4-naphthoquinone pH 7.0 Rattus norvegicus
1.6.5.2 222
-
 2,5-dimethyl-3,6-diaziridinyl-1,4-benzoquinone pH 7.0 Rattus norvegicus
1.6.5.2 242
-
 5-hydroxy-1,4-naphthoquinone pH 7.0 Rattus norvegicus
1.6.5.2 287
-
 2-methyl-1,4-benzoquinone pH 7.0 Rattus norvegicus
1.6.5.2 380
-
 2-methyl-1,4-naphthoquinone pH 7.0 Rattus norvegicus
1.6.5.2 431
-
 1,4-Naphthoquinone pH 7.0 Rattus norvegicus
1.6.5.2 500
-
 2-methyl-5-hydroxy-1,4-naphthoquinone pH 7.0 Rattus norvegicus
1.6.5.2 500
-
 2,5-dimethyl-1,4-benzoquinone pH 7.0 Rattus norvegicus
1.6.5.2 625
-
 2,6-dimethyl-1,4-benzoquinone pH 7.0 Rattus norvegicus
1.6.5.2 769
-
 1,4-benzoquinone pH 7.0 Rattus norvegicus
1.6.5.2 2331
-
 2,5-diaziridinyl-1,4-benzoquinone pH 7.0 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.6.5.2 NADPH
-
 Rattus norvegicus