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Literature summary extracted from

  • Pourreza, A.; Witherspoon, M.; Fox, J.; Newmark, J.; Bui, D.; Tolmasky, M.E.
    Mutagenesis analysis of a conserved region involved in acetyl coenzyme A binding in the aminoglycoside 6'-N-acetyltransferase type Ib encoded by plasmid pJHCMW1 (2005), Antimicrob. Agents Chemother., 49, 2979-2982.
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
2.3.1.82 D117A complete loss of the resistance phenotype against kanamycin and amikacin Escherichia coli
2.3.1.82 D120A complete loss of the resistance phenotype against kanamycin and amikacin Escherichia coli

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.82 Escherichia coli
-
 encoded by plasmid pJHCMW1
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.82 acetyl-CoA + amikacin
-
 Escherichia coli ?
-
 ?
2.3.1.82 acetyl-CoA + kanamycin
-
 Escherichia coli CoA + N6'-acetylkanamycin
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.82 aminoglycoside 6'-N-acetyltransferase type Ib
-
 Escherichia coli