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Literature summary extracted from

  • Wilson, C.R.; Sauer, J.M.; Carlson, G.P.; Wallin, R.; Ward, M.P.; Hooser, S.B.
    Species comparison of vitamin K1 2,3-epoxide reductase activity in vitro: kinetics and warfarin inhibition (2003), Toxicology, 189, 191-198.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.17.4.4 warfarin IC50: 0.00007 mM Bos taurus
1.17.4.4 warfarin
-
 Canis lupus familiaris
1.17.4.4 warfarin
-
 Equus caballus
1.17.4.4 warfarin IC50: 0.00018 mM, only one sample measured Homo sapiens
1.17.4.4 warfarin IC50: 0.00017 mM Mus musculus
1.17.4.4 warfarin
-
 Ovis aries
1.17.4.4 warfarin IC50: 0.00012 mM, only one sample measured Sus scrofa

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.17.4.4 0.00241
-
 vitamin K1 2,3-epoxide 37°C Ovis aries
1.17.4.4 0.00241
-
 vitamin K1 2,3-epoxide 37°C Equus caballus
1.17.4.4 0.00309
-
 vitamin K1 2,3-epoxide 37°C, only one sample measured Homo sapiens
1.17.4.4 0.0032
-
 vitamin K1 2,3-epoxide 37°C, only one sample measured Sus scrofa
1.17.4.4 0.0036
-
 vitamin K1 2,3-epoxide 37°C Canis lupus familiaris
1.17.4.4 0.00416
-
 vitamin K1 2,3-epoxide 37°C Mus musculus
1.17.4.4 0.00425
-
 vitamin K1 2,3-epoxide 37°C Bos taurus
1.17.4.4 0.00646
-
 vitamin K1 2,3-epoxide 37°C Bos taurus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.17.4.4 microsome
-
 Mus musculus
-
-
1.17.4.4 microsome
-
 Homo sapiens
-
-
1.17.4.4 microsome
-
 Sus scrofa
-
-
1.17.4.4 microsome
-
 Bos taurus
-
-
1.17.4.4 microsome
-
 Ovis aries
-
-
1.17.4.4 microsome
-
 Canis lupus familiaris
-
-
1.17.4.4 microsome
-
 Equus caballus
-
-

Organism

EC Number Organism UniProt Comment Textmining
1.17.4.4 Bos taurus
-
-
-
1.17.4.4 Canis lupus familiaris
-
-
-
1.17.4.4 Equus caballus
-
-
-
1.17.4.4 Homo sapiens
-
-
-
1.17.4.4 Mus musculus
-
-
-
1.17.4.4 Ovis aries
-
-
-
1.17.4.4 Sus scrofa
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.17.4.4 liver
-
 Mus musculus
-
1.17.4.4 liver
-
 Homo sapiens
-
1.17.4.4 liver
-
 Sus scrofa
-
1.17.4.4 liver
-
 Bos taurus
-
1.17.4.4 liver
-
 Ovis aries
-
1.17.4.4 liver
-
 Canis lupus familiaris
-
1.17.4.4 liver
-
 Equus caballus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.17.4.4 vitamin K1 2,3-epoxide + dithiothreitol
-
 Mus musculus vitamin K1 + oxidized dithiothreitol
-
 ?
1.17.4.4 vitamin K1 2,3-epoxide + dithiothreitol
-
 Homo sapiens vitamin K1 + oxidized dithiothreitol
-
 ?
1.17.4.4 vitamin K1 2,3-epoxide + dithiothreitol
-
 Sus scrofa vitamin K1 + oxidized dithiothreitol
-
 ?
1.17.4.4 vitamin K1 2,3-epoxide + dithiothreitol
-
 Bos taurus vitamin K1 + oxidized dithiothreitol
-
 ?
1.17.4.4 vitamin K1 2,3-epoxide + dithiothreitol
-
 Ovis aries vitamin K1 + oxidized dithiothreitol
-
 ?
1.17.4.4 vitamin K1 2,3-epoxide + dithiothreitol
-
 Canis lupus familiaris vitamin K1 + oxidized dithiothreitol
-
 ?
1.17.4.4 vitamin K1 2,3-epoxide + dithiothreitol
-
 Equus caballus vitamin K1 + oxidized dithiothreitol
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.17.4.4 VKOR
-
 Mus musculus
1.17.4.4 VKOR
-
 Homo sapiens
1.17.4.4 VKOR
-
 Sus scrofa
1.17.4.4 VKOR
-
 Bos taurus
1.17.4.4 VKOR
-
 Ovis aries
1.17.4.4 VKOR
-
 Canis lupus familiaris
1.17.4.4 VKOR
-
 Equus caballus
1.17.4.4 warfarin-sensitive vitamin K1 2,3-epoxide reductase
-
 Mus musculus
1.17.4.4 warfarin-sensitive vitamin K1 2,3-epoxide reductase
-
 Homo sapiens
1.17.4.4 warfarin-sensitive vitamin K1 2,3-epoxide reductase
-
 Sus scrofa
1.17.4.4 warfarin-sensitive vitamin K1 2,3-epoxide reductase
-
 Bos taurus
1.17.4.4 warfarin-sensitive vitamin K1 2,3-epoxide reductase
-
 Ovis aries
1.17.4.4 warfarin-sensitive vitamin K1 2,3-epoxide reductase
-
 Canis lupus familiaris
1.17.4.4 warfarin-sensitive vitamin K1 2,3-epoxide reductase
-
 Equus caballus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.17.4.4 0.00007
-
 IC50: 0.00007 mM Bos taurus warfarin
1.17.4.4 0.00012
-
 IC50: 0.00012 mM, only one sample measured Sus scrofa warfarin
1.17.4.4 0.00017
-
 IC50: 0.00017 mM Mus musculus warfarin
1.17.4.4 0.00018
-
 IC50: 0.00018 mM, only one sample measured Homo sapiens warfarin